Oral Microbiome: Beyond Bacteria

这份R13提案寻求对2021年福赛斯研讨会的支持，该研讨会的主题是口腔微生物组：超越细菌 福赛斯研究所，2021年10月28日至29日。研讨会的总体目标是更好地促进 从整体角度理解口腔微生物组。口腔微生物群由多种微生物群组成 细菌种类、真菌和病毒(噬菌体)成分，以及最近发现的纳米级 寄生候选叶霉菌(CPR)生物体。口腔微生物群相关问题的有效管理 疾病需要更全面地了解口腔微生物区系对宿主健康的影响 和疾病，这需要对不同成员之间的国内和国际互动有一个整体的看法 口腔微生物群(包括细菌、真菌、噬菌体和CPR生物体)以及微生物宿主 互动。研讨会将汇集一群具有不同研究背景的科学家进行口头交流 微生物组(包括口腔杆菌组、真菌组、噬菌体组和CPR)和不同的职业阶段 分享他们的研究和想法。研讨会将包括与会者的海报演示和演讲： 安·格里芬，马修·M·拉姆齐，古贤(米歇尔)，吉尔·班菲尔德，米尔莎·波达尔，杰夫·麦克莱恩，何学松， 凯瑟琳·考夫曼、大卫·莫耶斯、马哈茂德·加努姆、帕特里夏·迪亚兹、杰西卡·马克·韦尔奇、刘阳玉和 安娜·埃德伦德。另一个关键目标是确定生物学问题和必须 更全面地了解口腔微生物区系对宿主健康的影响 和疾病从整体的角度来看。同时，研讨会将推动新的合作 研究将从细菌物种间相互作用扩展到跨王国相互作用， 包括细菌、CPR、真菌和噬菌体。它还将为学员提供一个很好的互动机会 并促进他们的研究。更重要的是，通过鼓励女性实习生和 对于残疾或少数群体的受训人员，研讨会的目的是促进 牙科研究中代表性不足的群体。会议将创建一个调查人员社区，他们将 以前居住在彼此不相遇或交流的科学筒仓中：口腔细菌体， 真菌群、噬菌体和心肺复苏。这些调查人员现在将进行交流，并有望开发出 合作研究以实现从整体角度对口腔微生物组的基本理解， 这最终将提高我们诊断和治疗微生物感染的能力。

This R13 proposal seeks support for Forsyth Symposium 2021 “Oral Microbiome: Beyond Bacteria” at the Forsyth Institute on October 28-29, 2021. The overall objective of the symposium is to promote better understanding of oral microbiome from a holistic perspective. Oral microbiome is composed of diverse bacterial species, fungal and viral (bacteriophage) components, as well as recently identified nano-sized parasitic Candidate Phyla Radiation (CPR) organisms. Effective management of oral microbiome-related diseases calls for a more comprehensive understanding of the impact of the oral microbiota on host health and disease, which requires a holistic view of intra- and cross-kingdom interactions among different members of the oral microbiome (including bacteria, fungi, phages and CPR organisms), as well as microbial-host interaction. The symposium will bring together a group of scientists with diverse research backgrounds in oral microbiome (including oral bacsteriome, mycobiome, phageome and CPR) and different career stages to share their research and ideas. The Symposium will include poster presentations by attendees and talks by: Ann Griffen, Matthew M. Ramsey, Hyun (Michel) Koo, Jill Banfield, Mircea Podar, Jeff McLean, Xuesong He, Kathryn Kauffman, David Moyes, Mahmoud Ghannoum, Patricia Diaz, Jessica Mark Welch, Yang-Yu Liu, and Anna Edlund. Another key objective is to identify biological questions and technical roadblocks that must be overcome to achieve a more comprehensive understanding of the impact of the oral microbiota on host health and disease from a holistic point of view. Meanwhile, the symposium will promote new collaborative researches which will expand from bacterial interspecies interactions to inter-kingdom interactions which include bacteria, CPR, fungi, and phages. It will also provide a great opportunity for trainees to interact with experts in the field and promote their research. More importantly, by encouraging female trainees and trainees with disabilities or of minority groups, the symposium aims to promote the engagement of underrepresented groups in dental research. The conference will create a community of investigators who have previously resided in scientific silos that did not meet or communicate with each other: oral bacteriome, mycobiome, phageome and CPR. These investigators will now communicate and hopefully develop collaborative research to achieve a fundamental understanding of oral microbiome from a holistic perspective, which will ultimately improve our ability to diagnose and treat microbial infections.