Adapting MultiPLe behavior Interventions that eFfectively Improve (AMPLIFI) Cancer Survivor Health

项目总结 补编将在Amplifi P01(摘要如下)中增加措施，并加强其贡献。 给领养联盟。到2020年，美国癌症幸存者人数将超过2000万。癌 生存是一种胜利，但这是有代价的。一旦一个人被诊断出患有癌症，他们的风险要高得多。 罹患第二次癌症、心血管疾病、糖尿病、骨质疏松症和功能衰退的风险(下游影响 估计为1350亿美元/年)。不良饮食导致肥胖和缺乏体力活动与较差有关 癌症诊断后的结果。据推测，癌症幸存者可能能够改善他们的总体状况 通过改变生活方式来保持健康并减少合并症；特别是因为只有15%-47%的癌症幸存者 坚持国家关于体重状况、饮食和体力活动的指南。虽然有效地干预了性别歧视，但 几乎没有努力向最需要帮助的幸存者(老年人、农村人、少数族裔)传播这些广泛的范围。 还缺乏确定组合干预措施的最佳手段的研究，这一点至关重要，因为 许多幸存者都采取了多种次优行为。最主要的目标是：1)改善健康 癌症存活者的行为：多项次优健康行为；2)适应有效 通过技术优化覆盖范围的干预措施，同时还收集数据，为未来的传播和 这些干预措施的实施(D&I)潜力。Amplifi涉及3个高度相关的研究项目 由4个集成内核支持。它将征集652名患有多种癌症的幸存者的努力。 有利的5年存活率(过度抽样老年人、农村、少数民族)，并收集48个关键利益攸关方的投入。 具体目标：1)了解如何使有效的干预措施通过以下方式广泛传播 技术，同时保持推动行为改变的关键组件的完整性；2)优化 在许多癌症类型的老年、农村和少数民族幸存者中可接受和使用干预措施；3)测试 单独、按顺序或组合提供的适应性干预措施的有效性；4)有助于D&I研究 通过开发新的适应模型；以及5)确定提高距离- 提供健康行为改变干预措施，通过确定它们如何调解行为改变以及在谁身上进行 它们的效果最好。我们的最终目标是改善不断增长的癌症幸存者的健康。

PROJECT SUMMARY The supplement will add measures to the AMPLIFI P01 (abbreviated summary below) & enhance its contribution to the ADOPT Consortium. By 2020, the number of US cancer survivors will exceed 20 million. Cancer survivorship is a victory, but it comes at a price. Once a person is diagnosed with cancer, they are at much higher risk for 2nd cancers, cardiovascular disease, diabetes, osteoporosis, and functional decline (downstream effects estimated at$135 billion/year). A poor diet resulting in obesity and physical inactivity associates with poorer outcomes after a cancer diagnosis. It is hypothesized that cancer survivors may be able to improve their overall health and reduce comorbidity through lifestyle change; particularly since only 15-47% of cancer survivors adhere to national guidelines for weight status, diet and physical activity. While effective intervention sexist, there has been little effort to disseminate these broad scale and to survivors most in need (older, rural, minorities). There also is a dearth of research determining optimal means of combining interventions, which is critical since many survivors practice multiple suboptimal behaviors. The overarching aims AMPLIFI are: 1) improve health behaviors in cancer survivors who practice multiple suboptimal health behaviors; and 2) adapt efficacious interventions to optimize reach via technology while also collecting data to inform the future dissemination and implementation (D&I) potential of these interventions. AMPLIFI involves 3 highly interrelated research projects supported by 4 integrated cores. It will enlist the efforts of652 survivors of a broad array of cancers that have favorable 5-year survival rates (oversampling older, rural, minorities) and gather the input of 48 key stakeholders. Specific Aims: 1) Understand how to adapt efficacious interventions for widespread dissemination via technology, while maintaining the integrity of key components that drive behavior change; 2) Optimize acceptability and use of interventions among older, rural, minority survivors of many cancer types; 3) Test the efficacy of the adapted interventions delivered alone, in sequence, or combined; 4) Contribute to D&I research by developing a new adaptation model; and 5) Determine factors that improve the D&I potential of distance- delivered health behavior change interventions by determining how they mediate behavior change and in whom they work best. Our ultimate goal is to improve the health of the ever-increasing population of cancer survivors.