Africa Hepatopancreatobiliary Cancer Consortium

摘要 肝胆癌和胰腺癌是一组快速致命的恶性肿瘤， 病因学和生物学。这些癌症通常在晚期被诊断出来，在原发肿瘤已经扩散到 邻近或远处器官，排除治愈性治疗。非洲人患这些癌症的发病率高于 美国人、亚洲人或欧洲人。非洲人也更有可能在年轻时被诊断出患有这些癌症。 这些癌症的死亡率高于世界上许多其他种族/族裔群体。 在非洲肝胆和胰腺癌研究进展的重大限制是有限的 临床医生和科学家在新兴研究方面的持续培训，诊断能力有限， 尽管公众越来越多，但分配给肝癌、胆管癌和胰腺癌研究的资源有限， 这些癌症造成的健康负担。为了解决日益严重的高发病率问题， 为了降低非洲肝胆癌和胰腺癌的死亡率，迫切需要（1）确定并授权 新兴的癌症研究人员和临床医生在该领域的最新知识和研究技能， 有助于有意义地理解与这些癌症相关的病因学和预后因素， 和（2）帮助制定可持续的、实际的早期诊断行动，减少发病率， 这些癌症的死亡率。迫切需要利用我们的集体专门知识和资源， 美国与非洲研究人员合作，以促进非洲的肝胰胆管癌科学。 该提案将组织一系列肝胆胰科学研究研讨会， 由该领域的专家领导的癌症研究。讲习班将包括知识传授讲座， 这些癌症的病理生物学，设计适当的研究实验，具体到肝胆， 胰腺癌，手稿写作研讨会，设计研究人员之间的联合研究项目， 非洲和美国，为研究协调员提供项目管理培训， 实验室技术/技术。 在为期三年的R13赠款结束时，我们将加强非洲的专业知识， 美国，以解决肝胆癌和胰腺癌的长期高死亡率。通过 在这个项目中，我们将在非洲发展一个充满活力和合作的调查小组， 为推进肝胆癌和胰腺癌的科学做出有意义的贡献。预期 可交付成果还包括非洲人和美洲人之间的联合出版物和联合赠款申请 研究人员将加强在R13应用程序下实现的研究合作。的 我们的研究合作结果将提高对病因，生物学和 美国非裔和非裔人群中肝胆和胰腺癌的预后 States.

ABSTRACT Hepatobiliary and pancreatic cancers are a group of rapidly fatal malignancies with poorly understood etiology and biology. These cancers are often diagnosed at a late stage, after the primary tumor has spread to adjacent or distant organs, precluding curative therapy. Africans have higher incidences of these cancers than Americans, Asians, or Europeans. Africans are also more likely to be diagnosed with these cancers at younger ages and have a higher mortality from these cancers than many other racial/ethnic groups worldwide. Significant limitations to the advancement of hepatobiliary and pancreatic cancer research in Africa are limited continuous training in emerging research among clinicians and scientists, limited diagnostic capabilities, and the modest resources allocated to the liver, biliary and pancreatic cancer research despite the growing public health burden attributable to these cancers. To address the increasing problem of higher incidence and mortality of hepatobiliary and pancreatic cancers in Africa, there is a pressing need to (1) identify and empower emerging cancer researchers and clinicians with the most current knowledge and research skills in the field to contribute meaningfully to understanding the etiology and prognostic factors associated with these cancers, and (2) help develop sustainable, practical actions for early diagnosis and to reduce the incidence and mortality of these cancers in Africa. There an urgent need to harness our collective expertise and resources in the United States with African investigators to advance the science of hepatopancreatobiliary cancers in Africa. This proposal will organize a series of workshops on scientific research in hepatobiliary and pancreatic cancers led by experts in the field. The workshops will comprise of knowledge delivering lectures on the pathobiology of these cancers, design appropriate research experiments specific to hepatobiliary and pancreatic cancers, manuscript writing workshops, designing joint research projects among investigators in African and the United States, project management training for research coordinators, and training in new laboratory techniques/technology. At the conclusion of the three-year R13 grant, we will have enhanced the expertise in Africa and the United States to address the perennially high mortality rates of hepatobiliary and pancreatic cancers. Through this project, we will develop a vibrant and collaborative group of investigators in Africa, equipped with the skills to meaningfully contribute to advancing the science of hepatobiliary and pancreatic cancers. The expected deliverable also includes joint publications and joint grant applications among African and American investigators to augment the research collaboration that will be achieved under this R13 application. The results of our research collaborations will improve the understanding of the etiological factors, biology, and outcomes of hepatobiliary and pancreatic cancers in African and African-descent populations in the United States.