Cancer Epidemiology Research Program

摘要：癌症流行病学 癌症流行病学项目研究癌症和癌症的环境、遗传和分子风险 确定公共卫生和临床干预的优先事项。该计划有三个目标：（1）风险- 基于风险的预防和早期发现：确定基于风险的预防和早期发现的机会 （2）治疗、结局和生存率：改善癌症治疗、结局和生存率。 通过流行病学和临床研究进行循证干预，提高生存率;（3） 整合分子流行病学：加深对癌症病因学，异质性， 通过对前驱病变和肿瘤的综合人类分子和组织病理学研究， 一个主要的跨领域主题是解决健康差距的流行病学问题。作为一种综合性癌症 在一个经济，社会和种族多元化的国家的中心，行政长官是做好准备，以解决健康公平。 在这些目标中，我们使用多维度的北卡罗来纳州研究，并进行跨项目研究， 产生高影响力的发现。成员具有基于人口的流行病学、数据联系、 药物流行病学，调查研究，临床研究，筛选，分子和生物标志物研究， 转化临床前研究，社会学，病理学，基因组学，数据科学，计算机科学，和 统计学和流行病学方法。研究资源包括基于人群的乳腺、结肠、 前列腺癌、头颈癌以及乳腺癌和肺癌筛查登记。许多这些研究 参加大型国家和国际数据共享倡议和联盟。方案带来价值 通过收集暴露和结果数据的研究资源，以及生物标本， 共享资源（全州癌症数据）和流行病学方法的专业知识。该方案得到支持 这得益于Lineberger在教师招聘、共享资源和发展基金方面的投资。的 Lineberger战略计划强调优化北卡罗来纳州的癌症结果， 在人口科学领域进行重大投资，并在未来几年扩大新的领域， 子宫内膜和膀胱，并持续支持正在进行的乳腺癌和头颈癌数据收集， 颈部癌症CE计划由33名成员组成，他们与9个部门有联系， 查佩尔山及附属机构。在上一个资助期内，项目成员已出版776本 与癌症相关的文章中，24%是跨学科的，19%是学科内的（34%）。 协作）。2019年，我们的项目成员在癌症相关领域获得了总计1000万美元（直接成本）的赠款。 校外资金，包括来自NCI的520万美元（直接成本）和300万美元的其他同行评审资金。

ABSTRACT: CANCER EPIDEMIOLOGY PROGRAM The Cancer Epidemiology program studies environmental, genetic, and molecular risks for cancer and cancer outcomes to identify priorities for public health and clinical intervention. The program has three aims: (1) Risk- Based Prevention and Early Detection: To identify opportunities for risk-based prevention and early detection of cancer; (2) Treatment, Outcomes and Survivorship: To improve cancer treatment, outcomes, and survivorship through epidemiologic and clinical research that leads to evidence-based interventions; (3) Integrative Molecular Epidemiology: To deepen understanding of cancer etiology, heterogeneity, and survivorship through integrative human molecular and histopathologic studies of precursor lesions and tumors. A major cross-cutting theme is addressing the epidemiology of health disparities. As a comprehensive cancer center in an economically, socially, and racially diverse state, CE is well-poised to address health equity. Across these aims, we use multidimensional North Carolina studies and conduct cross-program research to yield high impact findings. Members have expertise in population-based epidemiology, data linkage, pharmacoepidemiology, survey research, clinical research, screening, molecular and biomarker research, translational preclinical research, sociology, pathology, genomics, data science, computer science, and statistical and epidemiologic methods. Research resources include population-based studies of breast, colon, prostate, head and neck cancer as well as registries for breast and lung screening. Many of these studies participate in large national and international data-sharing initiatives and consortia. The Program brings value to the Center through study resources that collect exposure and outcome data, and biospecimens, a unique shared resource (Statewide Cancer Data), and expertise in epidemiologic methods. The Program is supported by UNC Lineberger’s investments in faculty recruitments, shared resources and developmental funds. The UNC Lineberger strategic plan emphasis on optimizing cancer outcomes in North Carolina has led to significant investment across population sciences and is expanding in new areas in coming years including endometrium and bladder, with sustained support for ongoing data collection in breast cancer and head and neck cancers. The CE Program consists of 33 members who are associated with 9 departments at UNC- Chapel Hill and affiliated institutions. During the last funding period, program members have published 776 cancer-related articles, 24% were inter-programmatic and 19% were intra-programmatic (34% collaborative). In 2019, our program members held grants totaling $10.0M (direct cost) in cancer-relevant extramural funding, including $5.2M (direct costs) from the NCI and $3.0M other peer-reviewed funding.