Biobehavioral Factors and their Impact on Stress-Related Eating in Obesity

项目摘要/摘要 阐明导致饮食问题并最终增加体重风险的生物行为因素 鉴于肥胖症在美国的流行，增加是迫切需要的。而两国之间的关系 压力和饮食问题已经确立，但影响这种联系的其他因素仍然很差 明白了。影响进食压力关系的一个重要变量是 一个人会对有压力的情况做出反应。应激反应通常是通过皮质醇 对应激源的反应的变化。对于那些往往对压力高度敏感的人，在压力很大的时候， 他们似乎更有可能暴饮暴食。有证据表明，肠道微生物群会影响应激反应， 这似乎是影响压力-进食关系的一个重要生物学因素。另外， 对食物给予较高奖励的人在压力时刻可能更容易受到影响，可能 在这些情况下，最终会吃得过多或做出有问题的食物选择。在这项研究中，我们建议配对 生物和行为评估，以检验与压力相关的进食的新生物行为模型。 通过实验室和自然主义相结合的方法，我们将调查特定分类群在多大程度上 肠道微生物区系的基因、应激反应和食物的奖赏价值会调节进食压力。 两性关系。通过这种多方法的方法，我们还将使用瞬间和日常相结合的方法 评估以收集关于压力及其与饮食摄入量的关系的实时数据。这项研究将克服 先前研究的局限性，通过使用瞬时数据收集和生物和新的配对 行为变量。阐明在高压力时刻导致进食问题的关键因素 有可能导致个人化的减肥和预防肥胖的治疗方法。

PROJECT SUMMARY/ABSTRACT Elucidating the biobehavioral factors that lead to problematic eating, and ultimately increase the risk for weight gain, is critically needed given the epidemic of obesity in the United States. While the relationship between stress and problematic eating has been well-established, other factors that impact this association remain poorly understood. One important variable that appears to impact the stress-eating relationship is the manner in which one responds to stressful situations. Stress reactivity is commonly assessed by the manner in which cortisol changes in response to a stressor. For those who tend to be highly reactive to stress, in moments of high stress, they appear to be more likely to overeat. Evidence suggests that the gut microbiota influences stress reactivity, and this appears to be an important biological factor that influences the stress-eating relationship. Additionally, individuals who place a high reward value on food may be more impacted in moments of stress and may ultimately overeat or make problematic food choices in those instances. In this study, we propose to pair biological and behavioral assessment to examine the novel Biobehavioral Model of Stress-Related Eating. Through a combined laboratory and naturalistic approach, we will investigate the extent to which specific taxa and genes of the gut microbiota, stress reactivity, and the reward value of food moderate the stress-eating relationship. Through this multi-method approach, we will also use a combination of momentary and daily assessment to collect real-time data on stress and its association with dietary intake. This study will overcome limitations of prior research through its use of momentary data collection and novel pairing of biological and behavioral variables. Elucidating key factors that lead to problematic eating in moments of high stress has the potential to lead to personalized treatment approaches for weight reduction and the prevention of obesity.