Alcohol Use Before and After Bariatric Surgery: A Laboratory and Naturalistic St

描述（由申请人提供）：最近的研究结果显示，减肥手术后酒精的吸收速度加快，对酒精的敏感性提高。此外，据报道，在减肥手术后发生了几起与酒精有关的车祸和死亡。这篇文献支持了早期媒体的报道，这些报道表明饮酒频率和饮酒中毒率发生了重大变化。轶事和经验证据的结合导致了“成瘾转移”模型的发展。这一理论表明，在缺乏使用大量食物作为应对策略的能力的情况下，减肥手术后的患者可能会将这种行为换成另一种适应不良的行为，如酒精滥用。这些研究结果突出了目前缺乏相关领域的知识，酒精使用的频率，相关的情绪沉淀物和后果，以及减肥手术后的损害程度。在目前的研究中，我们建议检查两组患者的酒精使用情况：减肥手术前的患者和减肥手术后三到五年的患者。我们建议研究这些患者的实验室和自然的评估策略，努力最大限度地控制环境（实验室评估），并确保生态有效性的研究结果（自然评估）。我们相信，拟议的研究将提供关于减肥手术前后酒精使用的见解，以及有价值的试点数据，为一组减肥手术患者使用酒精的大规模，前瞻性，纵向研究。 公共卫生相关性：拟议的项目是特别重要的变化，发生在使用频率的理解，损害，和酒精使用前后的条件减肥手术。采用实验室和现场评估，目前的研究将提供严格控制和自然的结果，这将是高度信息化和临床相关的减肥手术患者。

DESCRIPTION (provided by applicant): Recent research findings show an accelerated rate of absorption and heightened sensitivity to alcohol following bariatric surgery. Additionally, several alcohol-related automobile accidents and deaths have been reported following bariatric surgery. This literature supports earlier media reports suggesting significant changes in frequency of alcohol use and rate of intoxication from drinking alcohol. The combination of anecdotal and empirical evidence has led to the development of an "addiction transfer" model. This theory suggests that in the absence of the ability to use large amounts of food as a coping strategy, post-bariatric surgery patients may exchange this behavior for an alternative maladaptive behavior such as alcohol misuse. These findings have highlighted the current lack of knowledge in the field related to the frequency of alcohol use, the associated mood precipitants and consequences, and level of impairment following bariatric surgery. In the current study we propose to examine the use of alcohol in two groups of patients: pre-bariatric surgery patients and patients three to five years post bariatric surgery. We propose to study these patients with both laboratory and naturalistic assessment strategies in an effort to maximize control of the environment (laboratory assessment) and to assure ecological validity of the findings (naturalistic assessment). We believe that the proposed study will provide insight regarding the use of alcohol before and after bariatric surgery as well as valuable pilot data for a large scale, prospective, longitudinal study of the use of alcohol in a group of bariatric surgery patients. PUBLIC HEALTH RELEVANCE: The proposed project is particularly important to the understanding of changes that occur in the frequency of use, impairment, and antecedent and consequent conditions of alcohol use before and after bariatric surgery. Employing both laboratory and field assessment, the current study will provide both tightly controlled and naturalistic findings, which will be highly informative and clinically relevant to bariatric surgery patients.