Core C - Neuroimaging and Informatics

核心C--项目摘要/摘要 复杂的信息学对任何多地点或协调的科学努力的成功至关重要， 支持以意想不到的方式重复使用数据和调查结果，大大增强了 项目。建议P01的核心C“血管对痴呆症的贡献和 阿尔茨海默病“将继续提供高质量的计算、协调和成像资源 对于项目1、2和3，核心B，以及所有P01调查人员、工作人员和授权科学家。CORE的活动 C将支持P01的科学目标以及更广泛的全国阿尔茨海默病(AD)和 痴呆症研究社区。 鉴于作为P01一部分收集的数据的多模式性质，稳健的信息学、数据 管理和协调至关重要。核心C将1)提供信息学数据管理框架 对于项目1和2，包括临床前和轻度认知期间轻微认知功能下降的诊断标准 AD的损害阶段，以及所有P01项目的统一成像数据。这种基于Web的集中式数据 该系统将用于参与者的登记和记录，包括基线登记和 跟踪、存档和跟踪原始和预处理的成像数据，并公开数据传播；2)确保 使用最先进的审查工作流程，高质量地控制P01项目中的所有神经成像数据 并评价弥散张量成像(DTI)、功能磁共振成像(FMRI)、结构磁共振成像 (MRI)、动态增强(DCE)MRI、动脉自旋标记(ASL)MRI和动态磁化率 对比度(DSC)MRI数据；3)为每个项目的每种成像方式提供统一的分析工作流程 通过用户友好、统一的数据分析管道，可以适应任何计算环境 所有调查人员均可访问；以及4)提供生物统计学支持(通过与核心A MPI合作，所有P01项目 以及核心领导者和合作研究人员，以及生物统计学家)，用于我们的分析方法、数据协调和 纵向数据建模。

CORE C – PROJECT SUMMARY/ ABSTRACT Sophisticated informatics is critical to the success of any multisite or coordinated scientific effort and enables subsequent re-use of data and findings in unanticipated ways greatly enhancing the overall value of the project. Core C of the proposed P01 “Vascular Contributions To Dementia And Genetic Risk Factors For Alzheimer’s Disease” will continue providing high quality computational, harmonization, and imaging resources for Projects 1, 2, and 3, Core B, and all P01 investigators, staff, and authorized scientists. The activities of Core C will support the scientific goals of the P01 as well as the broader national Alzheimer’s disease (AD) and dementia research community. Given the multimodality nature of data collected as a part of the P01, robust informatics, data management, and harmonization are critical. Core C will 1) provide an informatics data management framework for Projects 1 and 2 including diagnostic criteria for subtle cognitive decline during preclinical and mild cognitive impairment stages of AD, and harmonized imaging data for all P01 Projects. This centralized web-based data system will be used for registration and documentation of participants, including enrollment at baseline and follow-up, archival and tracking of raw and pre-processed imaging data and open data dissemination; 2) ensure high quality control of all neuroimaging data across P01 Projects using a state-of-the-art workflow for the review and assessment of diffusion tensor imaging (DTI), functional MRI (fMRI), structural magnetic resonance imaging (MRI), dynamic contrast-enhanced (DCE) MRI, arterial spin labeling (ASL) MRI, and dynamic susceptibility contrast (DSC) MRI data; 3) deliver a harmonized analysis workflow for each imaging modality for each Project that can accommodate any computational environment via a user-friendly, uniform data analysis pipeline that is accessible to all investigators; and 4) provide biostatistical support (by working with Core A MPIs, all P01 project and core leaders and co-investigators, and biostatisticians) for our analytic approaches, data harmonization, and modeling of longitudinal data.