COBRE in Digestive & Liver Disease

总体-项目摘要 消化和肝病卓越生物医学研究中心（COBRE）的总体目标 （CDLD）是为了在消化和肝脏疾病方面进行杰出的多学科合作研究， 南卡罗来纳州医科大学。这些疾病对南卡罗来纳州很重要， 他们给国家公民带来的巨大的、不成比例的负担。具体目标是：1） 指导、培训、招聘和留住一批早期职业科学家，使他们成为独立资助的研究人员 消化和肝脏疾病研究; 2）开发可持续的科学核心资源，以支持消化 和肝病研究，同时利用机构投资;和3）促进长期可行性， 通过发展多学科基础科学研究计划， 评估，持续改进策略，以及与MUSC其他中心的使命一致性。该中心是 由MUSC医学院的两个系主任组成的多学科团队领导， 资源，以实现其总体目标，即建立足够数量的有经费的调查员， MUSC将竞争未来外部同行评审的方案赠款支持。这一应用突出了四个 我们最优秀的初级研究员（JIs）将受益于创新的多源指导 该计划包括内部和外部导师。我们预计这些JI中的每一个都将过渡到 在项目的前三年内获得独立的NIH资助。CDLD还包括三个核心， 不仅支持JI，还支持整个医疗中心的消化和肝脏疾病研究人员。 科学核心包括：1）细胞模型核心，将产生消化和肝脏的先进细胞模型 2）消化系统疾病核心动物模型，这将提供获得和培训， 动物模型;以及3）先进的成像核心，提供先进的设备，技术和专业知识 这是成功的、最先进的基于细胞和组织的成像和分析所必需的。此外，CDLD将 通过促进跨学科的科学研究，促进消化和肝脏疾病研究人员之间的合作 通过我们的丰富活动进行交流，并通过我们的试点项目计划建立研究能力。 在NIH和机构的支持下，CDLD将实现我们的长期目标， 临床研究作为一个可持续的，多学科的，纲领性的中心。

Overall – Project Summary The overall goal of the Center of Biomedical Research Excellence (COBRE) in Digestive & Liver Diseases (CDLD) is to enable outstanding multidisciplinary collaborative research in digestive and liver diseases at the Medical University of South Carolina. These diseases are of importance to the state of South Carolina because of the tremendous, disproportionate burden they have upon the state’s citizens. The specific aims are to: 1) Mentor, train, recruit and retain a cadre of early career scientists to become independently funded investigators in digestive and liver diseases research; 2) Develop sustainable scientific core resources to support digestive and liver disease studies while leveraging institutional investments; and 3) Promote the long-term viability and success of the CDLD through development of multidisciplinary basic science research programs, rigorous evaluation, ongoing improvement strategies, and mission alignment with other centers at MUSC. The Center is led by a multidisciplinary team of two department chairs within the MUSC College of Medicine, coalescing resources to achieve their overarching objective of building a critical mass of funded investigators that will allow MUSC to compete for future external peer-reviewed programmatic grant support. This application highlights four of our most outstanding Junior Investigators (JIs) who will benefit from an innovative multiple source mentoring plan which features both internal and external mentors. We anticipate each of these JIs to transition to independent NIH funding within the first three years of the project. The CDLD also includes three Cores that will support not only the JIs but also digestive and liver disease investigators throughout the medical center. Scientific cores include the: 1) Cell Models Core, which will generate advanced cell models of digestive and liver diseases; 2) Animal Models of Digestive Disease Core, which will provide access to and training in essential animal models; and 3) Advanced Imaging Core, delivering sophisticated equipment, technologies and expertise required for successful, state-of-the-art cell and tissue-based imaging and analysis. Additionally, the CDLD will foster collaborations among digestive and liver disease researchers by promoting interdisciplinary scientific exchange through our enrichment activities and build research capabilities through our Pilot Project Program. With NIH and institutional support, the CDLD will attain our long-term goal of integratin basic, translational and clinical research as a sustainable, multidisciplinary, programmatic center.