Disaster Research Response (DR2) Core

灾难研究响应(DR2)核心摘要 德克萨斯A&M大学超级基金研究中心的总体主题是开发、应用和翻译 一套全面的工具和模型，将有助于减轻暴露对人类健康的影响 在与环境紧急情况有关的污染事件期间，对危险混合物的反应。在过去的资助期 (2017年以来)，该中心应对多起灾害，收集样本，回应来自 社区合作伙伴、非政府组织以及地方和州机构。活动包括抽样 水、沉积物和土壤对飓风哈维(2017)、飓风佛罗伦萨(2018)和 洲际码头公司(ITC)设施发生大规模工业火灾(2019年)。进行了抽样，以 建立危险物质再分布范围的空间和时间维度 可能影响人类健康的环境。而德克萨斯农工大学超级基金研究的几个 中心的项目和核心为这些努力做出了贡献，并提供了采样用品、现场人员、 培训和质量保证/控制(QA/QC)文档，我们现在建议建立一个专门的服务 这些活动的核心。因此，这款新的DR2酷睿将支持该中心，以及严谨和可重复性 DR2活动，确保中心通过建立一个集中的 用于支持DR2基础设施、方法、用品和培训的资源。DR2核心的中心假说 将确保DR2活动的严格性和可重复性，并确保中心应对未来 通过创建集中化的资源和基础设施来改善具有翻译研究的灾难 支持灾害研究响应，包括环境评估能力，可以迅速 部署在任何地方。DR2核心响应超级基金的任务(3)、方法的发展和 技术，以检测环境中的危险物质，并将侧重于四个具体目标。首先， DR2核心将维护以下项目所需的采样用品、现场和实验室设备以及仪器 收集灾害期间和灾害后的环境样本。第二，DR2核心将协调收集， 环境样品的处理和储存。第三，该核心将通过项目促进DR2活动 和核心，并与NIH DR2计划集成。最后，DR2核心将确保中心人员能够 安全和适当地进行现场工作，以进行基线采样和应对灾害。总体而言， DR2核心将特别增强中心项目和其他核心之间的互动，增加他们的 通过确保来自真实环境样本的测量/人类/测试系统暴露的一致性来产生影响 在决策、翻译和社区参与方面增加基础科学的翻译。

Disaster Research Response (DR2) Core ABSTRACT The overall theme of the Texas A&M University Superfund Research Center is to develop, apply, and translate a comprehensive set of tools and models that will aid in mitigating the human health consequences of exposure to hazardous mixtures during environmental emergency-related contamination events. In the past funding period (since 2017), the Center responded to a number of disasters to collect samples and respond to concerns from community partners, non-governmental organizations, and local and state agencies. Activities included sampling of water, sediment, and soils in response to Hurricane Harvey (2017), Hurricane Florence (2018), and the large- scale industrial fire at the Intercontinental Terminals Company (ITC) facility (2019). Sampling was conducted to establish both spatial and temporal dimensions of the extent of re-distribution of hazardous substances in the environment that may impact human health. While several of the Texas A&M University Superfund Research Center’s projects and cores have contributed to these efforts and provided sampling supplies, field personnel, training, and quality assurance/control (QA/QC) documentation, we now propose to establish a dedicated service core for these activities. Therefore, this new DR2 Core will support the Center, and the rigor and reproducibility of its DR2 activities, by ensuring the Center’s ability to respond to disasters through creation of a centralized resource to support DR2 infrastructure, methods, supplies, and training. The central hypothesis of the DR2 Core is that the rigor and reproducibility of DR2 activities will be ensured and the Center’s ability to respond to future disasters with translational research will be improved by creating a centralized resource and infrastructure to support disaster research response encompassing environmental assessment capabilities that can be rapidly deployed anywhere. The DR2 Core responds to Superfund mandate (3), the development of methods and technologies to detect hazardous substances in the environment, and will focus on four specific Aims. First, the DR2 Core will maintain sampling supplies, field and laboratory equipment, and instrumentation required for collection of environmental samples during and after disasters. Second, the DR2 Core will coordinate collection, processing, and storage of environmental samples. Third, this Core will facilitate DR2 activities by the projects and cores and integrate with NIH DR2 programs. Finally, the DR2 Core will ensure that Center personnel can conduct fieldwork safely and properly for baseline sampling and in response to disasters. Overall, the efforts of the DR2 Core will specifically enhance interactions among Center projects and other cores, increasing their impact by ensuring alignment of measured/human/test system exposures from real-life environmental samples and increasing the translation of basic science in decision making, translation, and community engagement.