Tissue Procurement Shared Facility

临床研究小组 组织采购共享设施(TPSF) 摘要 UAB综合癌症中心组织采购共享设施(TPSF)的目标是促进 UAB-CCC调查人员通过确保相关的、高素质的人力资源的可用性而进行的研究 纸巾。TPSF通过收集、处理、存储和分发大量的 人体组织的范围。肿瘤组织和对照组织以新鲜的、冷冻的、石蜡处理的形式提供 标本或组织切片。还可以提供体液和流体成分。病理学家评估 为质量和诊断准确性的研究提供的所有固体组织。补充服务 提供的，包括专门的组织学，大体解剖和定制的临床数据，都是可证明的 对UAB-CCC调查人员的意义以及TPSF与其他UAB-CCC有效合作的能力 CCC共享设施和附属公司。TPSF领导层为UAB提供专家个人指导- CCC研究人员在实验设计和有效使用新兴方法方面的基础和 翻译研究，以及确保在不断变化的监管环境中合规。这个 领导力的专业知识基于组织加工和银行领域的积极研究，以及他们的 参与地方、国家和国际各级的教育和外展计划。战略 规划已被用来利用机构和慈善资源，以扩大 在提高其业务的成本效益的同时，加强其设施。自那以来采取的举措 2011年包括大规模翻新、更新设备和统一标准作业-- 美国病理学家学会的认证程序.信息的持续改进 在降低劳动力成本的同时提高研究能力的技术应用；以及建立 Ccc组织银行。机构支持允许有针对性地招聘一名额外的病理学家 信息学专家，以及一名帮助TPSF的病理医生助理。TPSF为调查人员提供 所有六个UAB-CCC计划，自2011年以来，其参与的临床试验增加了两倍。它在以下方面发挥着核心作用 促进癌症中心的使命，提供来自非洲裔美国人患者的组织， 支持将它们纳入早期翻译研究。从2011年3月到2015年3月，TPSF一直在支持 来自57名UAB-CCC研究人员的请求，并支持了32项临床试验。1月到2月之间 2014年12月，该设施向38名UAB-CCC调查人员提供了919个新鲜或冷冻的人体组织 样本、754个石蜡块和12,925张幻灯片。据报道，由TPSF支持的研究已有120多项 这段时间内的出版物。自1978年以来，该设施已经提供了大约21.2万个组织 标本、积木和幻灯片交给UAB的调查人员。这些出版物共在1295份出版物中使用。

CLINICAL RESEARCH GROUP TISSUE PROCUREMENT SHARED FACILITY (TPSF) ABSTRACT The goal of the UAB Comprehensive Cancer Center Tissue Procurement Shared Facility (TPSF) is to promote the research undertaken by UAB-CCC investigators by ensuring the availability of relevant, high quality human tissues. The TPSF accomplishes this through the collection, processing, storage, and distribution of a wide range of human tissues. Neoplastic and control tissues are supplied as fresh, frozen, paraffin-processed specimens or tissue sections. Bodily fluids and fluid components also can be provided. Pathologists evaluate all solid tissues supplied for research for quality and diagnostic accuracy. The supplementary services provided, including specialized histology, macrodissection and customized clinical data, are of demonstrable significance to the UAB-CCC investigators as are the ability of the TPSF to work effectively with other UAB- CCC Shared Facilities and affiliates. The TPSF leadership provides expert individual guidance to the UAB- CCC investigators in experimental design and the effective use of emerging methodologies in basic and translational research, as well as ensuring compliance in the changing regulatory environment. The leadership's expertise is based on active research in the area of tissue processing and banking as well as their participation in educational and outreach programs at the local, national and international levels. Strategic planning has been used to harness institutional and philanthropic resources to expand the capabilities of the Facility while improving the cost-effectiveness of its operations. Initiatives that have been undertaken since 2011 include extensive renovations, updating of equipment and harmonization of standard-operating- procedures for accreditation by the College of American Pathologists; continued improvements in information technology applications that will enhance research capabilities while reducing labor costs; and establishment of the CCC Tissue Bank. Institutional support has permitted targeted recruitment of an additional pathologist, an informatics specialist, and a pathology physician's assistant to aid the TPSF. The TPSF serves investigators in all six UAB-CCC programs and since 2011 its involvement in clinical trials has tripled. It plays a central role in promoting the mission of the Cancer Center in terms of providing tissues from African-American patients that support their inclusion in early translational studies. From March 2011 to March 2015 the TPSF has supported requests from 57 UAB-CCC investigators and has supported 32 clinical trials. Between January and December 2014 the facility provided 38 UAB-CCC investigators with 919 fresh or frozen human tissue samples, 754 paraffin blocks, and 12,925 slides. TPSF-supported research has been reported in over 120 publications during this time period. Since 1978, the facility has provided approximately 212,000 tissue specimens, blocks, and slides to investigators at UAB. These have been used in a total of 1,295 publications.