Mentoring and Research in Biobehavioral Aspects of Pediatric Pain

项目摘要 这个K24应用程序的总体目标是扩展我目前的以患者为导向的研究（POR）， 指导将患者参与从研究到护理传播整合起来，以改善生物行为 照顾年轻人慢性MSK疼痛。这个奖项将提供关键的保护时间，以提高我的素质 以及对初级调查员（包括目前的K获奖者、未来的T-32）进行POR指导的数量 研究员和临床研究员（医生和心理学）。我目前支持的POR包括翻译 有针对性的生物心理社会评估纳入机械知情的治疗方法， 护理，再加上疼痛神经科学心理学，利用实验和神经成像方法， 获得与儿童功能结合的认知和情感过程的机械理解 和他们的父母。所有项目都利用无处不在的数字健康来增强患者的访问 和到达。我们的实验室拥有世界领先的专业知识，为患者提供理论和机制导向的研究， 家人通过该奖项支持的新研究方向侧重于获得新的专业知识 在科学严谨的定性和协同设计方法，与患者及其家属合作， 研究的阶段。本申请提出了两项研究，在我的长期指导机会， 长期研究目标是改善慢性疼痛青年的健康和福祉。研究1描述了 青少年肌肉骨骼（MSK）疼痛寻求，完成和反思疼痛护理的生活经验。 研究2的目的是共同设计一个优化我们的循证分级暴露治疗的青少年 患有慢性MSK疼痛和他们的父母，得到生活。K24建立在我以前的研究基础上，利用现有的 队列和数据，增加新的培训，并巩固与患者参与性研究领导者的合作 和定性数据分析，为下一代POR儿科疼痛提供有效的指导 科学家在K24奖的支持下，我将提高我的指导能力，我将努力提高我的 职业发展与我的学员，我的研究和我的专业发展相关的活动。 具体来说，我计划加深对定性数据方法和分析以及患者参与的理解。 研究方法此外，我将专门花时间确保继续进行法律的和道德问题方面的培训 与人类受试者和临床试验的研究相关，并加强我的专业领导能力。 拟议的研究提供了理想的背景，通过实践培训增加师友机会 和科学发展的生物行为方面的儿科慢性疼痛应用病人为中心 方法.有了K24的专门时间和培训，我将更好地指导下一代 POR儿科疼痛科学家，并编织一个以患者为中心的方法到所有研究从一开始， 执行.

Project Summary The overall objective of this K24 application is to expand my current patient-oriented research (POR) and mentoring to integrate patient engagement from research to dissemination of care to improve the biobehavioral care of youth with chronic MSK pain. This award will provide the crucial protected time to enhance my quality and quantity of mentoring of junior investigators focused on POR including current K awardees, future T-32 fellows, and clinical fellows (physician and psychology). My currently supported POR encompasses translating targeted biopsychosocial assessments into mechanistically informed treatment approaches for optimal clinical care, coupled with pain neuroscience psychology that leverages experimental and neuroimaging methods to gain a mechanistic understanding of cognitive and affective processes that coalesce with function in children with chronic pain and their parents. All projects leverage the ubiquity of digital health to enhance patient access and reach. Our lab has world-leading expertise in theory- and mechanism-oriented research for patients and their families. The new direction of research to be supported through this award focuses on gaining new expertise in scientifically rigorous qualitative and codesign methods to partner with patients and their families across all stages of research. This application proposes two studies with significant mentoring opportunities within my long- term research objective to improve the health and well-being of youth with chronic pain. Study 1 characterizes the lived experience of youth with musculoskeletal (MSK) pain seeking, completing, and reflecting on pain care. Study 2 aims to codesign an optimization of our evidence-based graded exposure treatment for adolescents with chronic MSK pain and their parents, GET Living. The K24 builds on my previous research, leverages existing cohorts and data, adds new training, and solidifies collaborations with leaders in patient participatory research and qualitative data analysis to provide effective mentorship to the next generation of POR pediatric pain scientists. With support from the K24 award, I will enhance my mentoring capacity and I will work to enhance my career development with activities relevant to my mentees, my research, and my professional development. Specifically, I plan to deepen my understanding of qualitative data methods and analysis and patient participatory research methods. Moreover, I will dedicate time to ensure continued training in legal and ethical issues associated with research on human subjects and clinical trials and strengthen my professional leadership skills. The proposed studies provide the ideal context for enhancing mentorship opportunities via hands-on training and scientific development in the biobehavioral aspects of pediatric chronic pain applying patient-centered methods. With dedicated time and training from the K24, I will be better equipped to mentor the next generation of POR pediatric pain scientists and weave a patient-centered approach into all research from inception to execution.