A Latin American biobank for large-scale genetics research on severe mental illness

项目总结/摘要 NIMH资助R 01 MH 123157（拉丁美洲严重精神疾病生物库[LAB-SMI]）的补充 将使加州大学洛杉矶分校的研究人员能够为这个项目建立一个DNA储存库。父项目 旨在扭转拉丁美洲人口在精神病遗传学研究中的代表性不足。它将 通过从哥伦比亚招募92，000名新参与者（42，000名被诊断患有 SMI和50，000名人群对照），并从这些参与者中获取血液样本， 用于全基因组遗传研究的DNA。补充资金将用于资助调查人员， 建议在父母补助金的DNA提取和储存，以便：（1）获得更大量的高质量的 （2）保存和跟踪DNA样本，以便于在特定用途之外使用样本。 父母补助金的目的;（3）根据协议向合格的调查人员提供DNA等分试样 与NIMH计划工作人员一起建立。该补充将添加到父项目的价值作为一个独特的 第一个在拉丁美洲人群中进行的精神疾病的有力遗传研究的资源 祖先和探索SMI表型的遗传结构。

PROJECT SUMMARY / ABSTRACT This supplement to NIMH grant R01 MH123157 (Latin American Biobank of Severe Mental Illness [LAB-SMI]) will enable the UCLA investigators of this project to establish a DNA repository for this project. The parent project aims to reverse the underrepresentation of populations from Latin America in psychiatric genetic research. It will do so by recruiting and phenotyping 92,000 new participants from Colombia (42,000 individuals diagnosed with SMI and 50,000 population controls) and obtaining blood samples from these participants that will provide the DNA for genome wide genetic studies. The supplement will fund the investigators to augment the processes proposed in the parent grant for DNA extraction and storage so as to: (1) obtain larger amounts of high-quality DNA; (2) store and track the DNA samples in a way that will facilitate the use of the samples beyond the specific aims of the parent grant; (3) make aliquots of DNA available to qualified investigators based on protocols established with NIMH program staff. The supplement will add to the value of the parent project as a unique resource for the first well-powered genetic studies of psychiatric disorders in populations of Latin American ancestry and for exploring the genetic architecture of SMI phenotypes.