Cognitive and Neurobiological Approaches to Plasticity (C-NAP) Center

项目总结 这一阶段科布雷的结果是建立了一个独特的、关于认知和 可塑性的神经生物学方法(CNAP)。研究项目和试点拨款检查认知/神经 在人类和动物中利用基本的和翻译/应用的方法，在整个生命周期内保持可塑性 模特们。最终目标是确定认知和神经可塑性所涉及的机制 改善功能。三个研究核心设施支持研究项目、试点拨款和计划：a 行为神经科学核心(BN)、脑电(EEG)核心和神经信息学核心 (Ni)在堪萨斯州内提供独特的研究基础设施资源。国阵核心经历了 2017年的重大翻新(总成本近100万美元)，包括设施和设备升级到共享 使用外科和湿法实验室。还安装了一个新的笼子清洗设施，以支持增加的动物 住房容量。这些升级增强了这个核心支持尖端动物神经科学的能力 研究。这一核心资助了两个项目和一个试点赠款，国家行动计划预计将资助一个项目。 以及一项试点赠款，将在来年使用这一核心。目前的补编将加强这一点 通过购买新的低温恒温器作为升级并最终取代目前过时的 单位。所有五个使用这个核心的实验室都严重依赖低温恒温器，而且没有足够的后备设备 校园内的资源，所以这次升级将确保研究的连续性。脑电核心建立于 2018作为新的多用户核心，支持人类认知神经科学研究。此核心已支持 两笔试点赠款和一个项目，该中心预计将在#年支持一个试点项目和一个主要项目 即将到来的拨款年度将使用这一核心。本附录将支持对当前 已经过时的功放。为了扩展此核心的功能，CNAP将购买一个重复的 支持神经调节研究的跨磁刺激系统。这代表着一个重要的 核心将能够支持的研究技术的进步。NI核心成立于 2017作为新的核心，与Beocat高性能计算设施相结合。此核心支持所有项目 和试点赠款，并直接与CNAP科学交流中的EEG核心和其他两个核心对接 网络(堪萨斯大学医学中心和小动物的霍格伦德脑成像中心 成像核磁共振/核磁共振K-态化学核心)。本补充内容将升级文件系统以支持 数据密集型神经成像分析和建模活动可将性能提高10,000倍 当前的通用系统。此次升级将创造支持尖端分析的机会 为CNAP资助的所有项目和试点赠款提供技术。总体而言，本附录中的升级提供了 多方面机会支持CNAP的成功和发展，以确保中心的高供应 高质量的设备和尖端技术，促进CNAP初级调查人员的成功。

PROJECT SUMMARY This Phase 1 COBRE resulted in the establishment of a unique, thematic research center on Cognitive and Neurobiological Approaches to Plasticity (CNAP). Research projects and pilot grants examine cognitive/neural plasticity across the lifespan, utilizing basic and translational/applied approaches in humans and animal models. The ultimate goal is to determine the mechanisms involved in cognitive and neural plasticity to improve functioning. Three research core facilities support the research projects, pilot grants, and programs: a Behavioral Neuroscience Core (BN), an Electroencephalography (EEG) Core, and a Neuroinformatics Core (NI), supplying unique research infrastructure resources within the State of Kansas. The BN core underwent major renovations in 2017 (nearly $1M in total costs) which included facility and equipment upgrades to shared user surgical and wet laboratories. A new cage wash facility was also installed to support increased animal housing capacity. The upgrades enhanced the ability of this core to support cutting-edge animal neuroscience research. This core has supported two projects and one pilot grant and CNAP anticipates funding one project and one pilot grant that will use this core in the coming grant year. The current supplement will enhance this core through the purchase of a new cryostat as an upgrade and eventual replacement for the current outdated unit. All five laboratories that use this core rely heavily on the cryostat and there are insufficient back-up resources on campus, so this upgrade will ensure continuity of research. The EEG core was established in 2018 as a new multi-user core to support human cognitive neuroscience research. This core has supported two pilot grants and a project, and the center anticipates supporting one pilot project and a primary project in the coming grant year that will use this core. This supplement will support a critical upgrade to the current amplifier which is becoming outdated. To expand the functionality of this core, CNAP will purchase a repetitive transmagnetic stimulation system to support neuromodulation research. This represents a significant advancement in the research techniques that the core will be able to support. The NI core was established in 2017 as a new core, tied in with the Beocat high-performance computing facility. This core supports all project and pilot grants and directly interfaces with the EEG core and two other cores in the CNAP scientific exchange network (the Hoglund Brain Imaging Center at the University of Kansas Medical Center and the Small Animal Imaging NMR/MRI Core in Chemistry at K-State). This supplement will upgrade the file system for supporting data-intensive neuroimaging analysis and modeling activities to increase performance by 10,000x over the current general-purpose system. This upgrade will create opportunities to support cutting-edge analysis techniques for all CNAP funded projects and pilot grants. Overall, the upgrades in this supplement provide multi-faceted opportunities to support the success and growth of CNAP to ensure the center supplies high quality equipment and cutting-edge technologies to promote the success of CNAP junior investigators.