Biobehavioral Shared Resource

生物行为共享资源摘要 生物行为共享资源(BBSR)的首要目标是提高其可行性和成功性 摩尔癌症中心(MCC)的研究人员研究生活方式行为和 干预措施以及癌症结局的生物学指标，以降低癌症风险和提高存活率 在被诊断出癌症之后。服务请求提供开发和运营方面的专业知识和指导 为不一定在这些领域拥有专业知识的MCC成员或具有 资源有限，无法使用基于科学的高质量方法，而不具备 整合的服务核心。BBSR提供三类服务：(1)生物指标 用于确定分子机制的行为和评估，(2)行为评估，和(3) 行为干预。生物指标评估服务包括制定议定书，以便 生物菌素的收集和加工.加工和储存的程序的开发和提供 和/或样品运输；以及直接为采血、样品处理、样品制备提供服务。 分析(例如，DNA提取)和分析。行为评估服务包括提供设备， 培训和数据处理，以提高体力活动和久坐的数据收集质量 行为评估.基于电话的饮食召回和身体测量的直接服务 并协助进行基于网络的24小时饮食回忆和饮食历史问卷调查。行为 干预服务包括对干预设计和内容的指导，基于理论基础和 经验性支持的减肥、饮食和体力活动干预；为 有针对性的干预措施，以满足研究人群的需求和行为结果； 监督和质量控制；提供指导和最佳实践，以使用各种新的 自我监测的技术和通信方式。因此，BBSR提供了访问 生活方式行为和生物因素评估方面的专门技术、服务和专业知识 加强科学互动和生产力，使MCC成员能够成功地获得资金和 在同行评议的、有影响力的期刊上发表文章。BBSR由一名系主任、联席主任和 高素质的运营人员，在这些科学和技术领域拥有必要的专业知识 技术领域。此外，BBSR有一个坚实的领导和继任计划。对于一个相对的 投入不多，SR工作人员正在支持MCC PI进行的以癌症为重点的行为研究，而MCC PI无法 否则，继续前进。自上次CCSG审查以来，该资源继续为科学研究做出贡献 在许多重大赠款和项目上的努力。

BIOBEHAVIORAL SHARED RESOURCE ABSTRACT The overarching goal of the Biobehavioral Shared Resource (BBSR) is to enhance the feasibility and success of Moores Cancer Center (MCC) investigators studying the link between lifestyle behaviors and effect of interventions, as well as biological indicators of cancer outcome, to reduce cancer risk and increase survival following the diagnosis of cancer. The SR provides expertise and guidance in developing and operationalizing behavioral research for MCC members who do not necessarily have expertise in these areas, or who have limited resources to use high-quality, science-based methodology without the context and efficiency of a consolidated service core. The BBSR provides services across three categories: (1) biological indicators of behavior and assessment for determining molecular mechanisms, (2) behavioral assessment, and (3) behavioral interventions. Biological indicators assessment services include development of protocols for biospecimen collection and processing; development and provision of procedures for the processing, storing and/or shipping of samples; and direct services for phlebotomy, sample processing, preparation of samples for analysis (e.g., DNA extraction), and analysis. Behavioral assessment services include providing devices, training, and processing of data to improve the quality of data collection for physical activity and sedentary behavior assessment; direct services for telephone-based dietary recalls and measurement of body composition; and assistance with web-based 24-hour dietary recalls and diet history questionnaires. Behavioral intervention services include guidance on intervention design and content based on theoretically-grounded and empirically-supported weight loss, diet and physical activity interventions; protocol development for interventions that are specifically targeted to meet the needs of study populations and behavioral outcomes; supervision and quality control; and providing guidance and best practices for using a variety of new technologies and communication modalities for self-monitoring. Thus, the BBSR provides access to specialized technologies, services and expertise in lifestyle behavior and assessment of biological factors that enhance scientific interaction and productivity, enabling MCC members to successfully obtain funding and publications in peer-reviewed, high-impact journals. The BBSR is led by a Faculty Director, Co-Directors, and operations staff who are highly qualified, with the requisite expertise across the scope of these scientific and technical areas. Furthermore, the BBSR has a solid leadership and succession plan in place. For a relatively modest investment, SR staff are enabling cancer-focused behavioral studies by MCC PIs that could not otherwise go forward. Since the prior CCSG review, the resource has continued to contribute to scientific efforts in numerous major grants and projects.