Brain Structure in Adults with FASD - L. Aguilar diversity supplement

项目摘要 产前酒精暴露会对发育中的胎儿产生毁灭性的影响，包括 发育缺陷、认知和行为异常、大脑改变和面部明显异常 特征；统称为胎儿酒精谱系障碍(FASD)。 虽然已经有很多研究检测了FASD儿童的大脑和行为， 关于成年人的数据非常少。PAE的许多后果被认为是终生的，但 有关已过青壮年的个人的数据很少。之前在华盛顿州西雅图进行的大型研究 开发了具有良好特征的个人研究样本，其分类为 FASD和年龄和性别匹配的对照组。这些受试者中有180完成了T1- 加权核磁共振扫描大约在20年前。在这些先前扫描的受试者中，有50人 已经被招募来完成后续的T1加权MRI扫描，作为父母的一部分 获奖。家长奖的目的是评估产前饮酒的长期影响 暴露在大脑上，特别是在前述的额叶执行系统内 数据集。该项目通过评估额外的与年龄相关的项目来扩展父母的补助 大脑皮质下感兴趣区(ROI)的变化。本增刊将支持 实习生林赛·阿吉拉尔在获得人类神经成像研究和 为父母奖的目标做出了贡献，“患有FASD的成年人的大脑成熟”。更多 具体地说，阿吉拉尔将利用现有的神经成像软件程序来应用 用于基线和后续扫描数据的皮质下ROI形状的贝叶斯模型。对于目标1， 她将使用两种不同的技术来处理基线数据，以估计可能的形状 (FSL/First和使用Enigma管道的Freesurfer)，以确定哪条管道最有效。 在选择了更合适的管道后，她将比较成年人和 将FASD与使用随访数据的匹配对照进行比较。作为她训练计划的一部分， 她将完成Freesurfer和FSL提供的教程和短期课程，参加和 在人类大脑图谱和酒精中毒研究学会上展示她的数据 会议。此外，她将完成职业发展活动，因为她赚到了 拥有硕士学位，从事研究产前酒精影响的研究工作 暴露在大脑上。

Project Summary Prenatal alcohol exposure can have devastating effects on the developing fetus, including growth deficits, cognitive and behavioral anomalies, alterations in brain, and distinct facial characteristics; collectively these are referred to as fetal alcohol spectrum disorders (FASD). While there has been much research examining the brain and behavior in children with FASD, very little data exists on adults. Many of the consequences of PAE are thought to be lifelong, yet data on individuals past young adulthood are rare. Previous large studies from Seattle, WA developed well-characterized research samples of individuals with a classification of having an FASD and age- and sex-matched controls. One-hundred-eighty of these subjects completed T1- weighted MRI scans approximately 20 years ago. Fifty of these previously scanned subjects have already been recruited to complete a follow-up T1-weighted MRI scan as part of the parent award. The aim of the parent award is to evaluate the protracted effects of prenatal alcohol exposure on the brain, particularly within the frontal executive system from the aforementioned dataset. This project expands upon the parent grant by evaluating additional age-related changes in the brain within subcortical regions of interest (ROIs). This supplement will support the trainee, Lindsey Aguilar, as she acquires skills in human neuroimaging research and contributes to the goals of the parent award, “Brain maturation in adults with FASD.” More specifically, Ms. Aguilar will utilize available neuroimaging software programs to apply a Bayesian model of shape to subcortical ROIs for baseline and follow-up scan data. For Aim 1, she will process the baseline data with two different techniques for estimating probable shape (FSL/FIRST and FreeSurfer with Enigma pipeline) to determine which pipeline is most effective. After choosing the more appropriate pipeline, she will compare shape differences in adults with FASD as compared to matched controls using the follow-up data. As part of her training plan, she will complete tutorials and short courses offered by both FreeSurfer and FSL, attend and present her data at the Human Brain Mapping and Research Society on Alcoholism conferences. Additionally, she will be completing career development activities as she earns her master’s degree and pursues a research career studying the impact of prenatal alcohol exposure on the brain.