CNS DEFICITS: INTERACTION OF AGE & ALCOHOLISM

中枢神经系统缺陷：年龄的相互作用

• 批准号: 7722857
• 负责人: Adolf Pfefferbaum
• 金额: $ 0.56万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7722857
• 关键词: Age; Alcoholism; Behavioral; Brain scan; Cholinergic Agents; Computer Retrieval of Information on Scientific Projects Database; Corpus striatum structure; Data; Funding; Grant; Institution; Length; Magnetic Resonance Imaging; Measures; Medial; Methods; Nucleus Accumbens; Patients; Recovery; Research; Research Personnel; Resources; Schizophrenia; Short-Term Memory; Source; Structure; Syndrome; United States National Institutes of Health; Wernicke-Korsakoff Syndrome; alcohol exposure; basal forebrain; caudate nucleus; cholinergic; drinking; grasp; problem drinker; putamen; sobriety

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Aims: The aims of this project are to continue analysis of longitudinal and cross-sectional MRI and behavioral data previously collected at the Lucas Center Methods and Results: We have completed further analysis of volumetric measures of striatal (caudate nucleus, putamen, nucleus accumbens) and basal forebrain [medial septum/diagonal band (MS/BD)] structures measured on 3D brain scans obtained from patients with alcoholism (n = 25), Korsakoff's Syndrome (n = 6), schizophrenia comorbid for alcoholism (n = 19) and healthy controls (n = 51). Volumes of caudate and putamen were smaller in the alcoholics than the controls, regardless of length of sobriety. However, the nucleus accumbens showed marked sensitivity to recent alcohol exposure, with greater deficits in recently drinking than sober alcoholics (whether or not they were comorbid for schizophrenia) and no deficits in long sober KS. Among alcoholics, putamen volume was positively correlated with grip strength and MS/DB volume was positively correlated with verbal working memory independently of the negative association between age-standardized MS/DB and age in alcoholics. MS/DB was also reduced in KS. Conclusions: The nucleus accumbens may show recovery with sobriety among alcoholics. Deficits in putamen and MS/DB volumes in alcoholism have functional significance. MS/DB volume loss and potential accompanying cholinergic compromise may also contribute to the KS amnesic syndrome.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 目标：该项目的目标是继续分析先前在卢卡斯中心收集的纵向和横截面 MRI 以及行为数据 方法和结果：我们完成了对纹状体（尾状核、壳核、伏隔核）和基底前脑 [内侧隔膜/对角带 (MS/BD)] 结构的体积测量的进一步分析，这些结构是通过从酒精中毒 (n = 25)、科萨科夫综合征 (n = 6)、酒精中毒合并症精神分裂症 (n =) 患者获得的 3D 脑扫描获得的。 19) 和健康对照 (n = 51)。无论清醒时间长短，酗酒者的尾状核和壳核体积都比对照组小。 然而，伏核对最近的酒精暴露表现出明显的敏感性，与清醒的酗酒者相比，最近饮酒的缺陷更大（无论他们是否患有精神分裂症），而长期清醒的 KS 则没有缺陷。 在酗酒者中，壳核体积与握力呈正相关，MS/DB 体积与言语工作记忆呈正相关，与酗酒者年龄标准化 MS/DB 和年龄之间的负相关无关。 KS 中的 MS/DB 也有所减少。 结论：酗酒者清醒时伏隔核可能会恢复。 酗酒时壳核和 MS/DB 体积的缺陷具有功能意义。 MS/DB 容量损失和潜在的胆碱能损害也可能导致 KS 遗忘综合征。