CNS DEFICITS: INTERACTION OF AGE & ALCOHOLISM

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。方法和结果：我们完成了对纹状体(尾状核、壳核、伏隔核)和基底前脑[内侧隔/斜角带(MS/BD)]结构体积测量的进一步分析，这些结构来自酒精中毒患者(n=25)、柯萨科夫-S综合征(n=6)、精神分裂症合并酒精中毒患者(n=19)和健康对照组(n=51)。不管戒酒的时间长短，酗酒组的尾状核和壳核的体积都比对照组小。然而，伏隔核对最近的酒精暴露表现出明显的敏感性，最近饮酒的缺陷比清醒的酒精者更严重(无论他们是否患有精神分裂症)，而长期清醒的KS没有缺陷。在酗酒者中，壳核体积与握力呈正相关，MS/DB体积与言语工作记忆呈正相关，与年龄标准化的MS/DB与年龄负相关无关。KS的MS/Db也降低了。结论：酒精性伏隔核在清醒状态下可能恢复正常。酒精中毒患者的壳核和MS/DB体积缺陷具有一定的功能意义。MS/DB容量减少和潜在的胆碱能折衷也可能导致KS遗忘综合征。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Aims: The aims of this project are to continue analysis of longitudinal and cross-sectional MRI and behavioral data previously collected at the Lucas Center Methods and Results: We have completed further analysis of volumetric measures of striatal (caudate nucleus, putamen, nucleus accumbens) and basal forebrain [medial septum/diagonal band (MS/BD)] structures measured on 3D brain scans obtained from patients with alcoholism (n = 25), Korsakoff¿s Syndrome (n = 6), schizophrenia comorbid for alcoholism (n = 19) and healthy controls (n = 51). Volumes of caudate and putamen were smaller in the alcoholics than the controls, regardless of length of sobriety. However, the nucleus accumbens showed marked sensitivity to recent alcohol exposure, with greater deficits in recently drinking than sober alcoholics (whether or not they were comorbid for schizophrenia) and no deficits in long sober KS. Among alcoholics, putamen volume was positively correlated with grip strength and MS/DB volume was positively correlated with verbal working memory independently of the negative association between age-standardized MS/DB and age in alcoholics. MS/DB was also reduced in KS. Conclusions: The nucleus accumbens may show recovery with sobriety among alcoholics. Deficits in putamen and MS/DB volumes in alcoholism have functional significance. MS/DB volume loss and potential accompanying cholinergic compromise may also contribute to the KS amnesic syndrome.