Bioinformatics Core

项目摘要/摘要 生物信息学核心 该核心的目的是提供转录组数据的生物信息分析。我们的核心将提供 基本数据分析服务，使本组织的成员能够访问和解释这些数据 财团。该中心的董事和工作人员在基因组数据分析方面拥有丰富的经验，如 并熟悉相关项目的基本生物学知识。具体地说，我们将处理批量、 使用现有管道的单细胞和空间转录数据。此外，我们还开发了工具来 根据细胞类型和炎症信号解释转录图谱。我们还拥有专业知识， 使用数据集成工具将我们的转录组数据与基因和脂肪组数据结合在一起。最后，我们会 提供数据可视化工具，例如用于在二维中查看单个基因的R闪亮服务器 单细胞转录本的投影。我们在这里提议的核心将允许此中的所有组 CORT接收经分析的数据，研究人员无需大量计算即可直接解释这些数据 专业知识。这一功能应该使基因组学研究更容易为本组织的所有成员所接受 科特。

PROJECT SUMMARY/ABSTRACT Bioinformatics Core The purpose of this Core is to provide bioinformatic analysis of transcriptomic data. Our Core will provide the essential data analysis service to render this data accessible and interpretable to the members of this consortium. The directors and staff of this Core have extensive experience in the analysis of genomic data, as well as familiarity with the underlying biology of the associated projects. Specifically, we will process bulk, single cell and spatial transcriptomic data using existing pipelines. Moreover, we have developed tools to interpret transcriptomic profiles in terms of cell type and inflammatory signatures. We also have expertise in the use of data integration tools to combine our transcriptomic data with genetic and lipidomic data. Finally, we will provide tools for data visualization, such as an R Shiny server for viewing individual genes in two dimensional projections of single cell transcriptomes. The Core we are proposing here will allow all the groups within this CORT to receive analyzed data that can be directly interpreted by researchers without extensive computational expertise. This functionality should render genomics research far more accessible to all members of this CORT.