Adult Changes in Thought (ACT) Research Program Core E: Neuroimaging Core

核心E：ACT神经成像核心摘要/摘要 神经成像核心提供技术和分析专业知识，以阐明 对所有U19项目和核心进行了复杂的神经生物老化过程研究。核心的目标 包括收集和分析新MRI扫描、收集和分析死后高分辨率EX 活体脑MRI扫描与切除的脑组织对齐，检查图像引导的组织采样 补充神经病理分析，以及机器学习和人工智能(AI)的应用 增强在ACT参与者中收集的将支持项目和其他核心的成像数据的技术 在ACT U19计划中。神经成像核心将利用数据科学技术并应用严格的 方法分析从ACT参与者收集的纵向影像数据如何与相关临床、 遗传、神经病理学、实验室和药学信息。神经成像核心将创造协同效应 通过向项目提供数据和提供成像分析，帮助整合 通过与其他核心的密切合作，特别是与神经病理学和数据和 分析核心，并将作为在计划中出现的知识和想法共享的渠道，所有 其中帮助ACT U19计划完成的项目比单个项目单独完成的要多。

CORE E: ACT NEUROIMAGING CORE Summary/Abstract The Neuroimaging Core provides the technical and analytic expertise to elucidate interactions between the complex neurobiological aging processes studied across all U19 Projects and Cores. The Aims of the core include collection and analysis of new MRI scans, collection and analysis of post-mortem high resolution ex vivo brain MRI scans for alignment with the excised brain tissue, examination of image-guided tissue sampling to supplement neuropathological analysis, and the application of machine learning and artificial intelligence (AI) techniques to enhance imaging data collected in ACT participants that will support the Projects and other cores in the ACT U19 Program. The Neuroimaging Core will leverage data science techniques and apply rigorous methods to analyze how longitudinal imaging data collected from ACT participants interact with related clinical, genetic, neuropathological, laboratory, and pharmacy information. The Neuroimaging Core will create synergy within the Program by contributing data and providing imaging analyses to the Projects, helping to integrate the Program through close collaboration with the other Cores especially the Neuropathology and Data and Analysis Cores, and will work as a conduit for sharing knowledge and ideas as they arise in the Program, all of which helps the ACT U19 Program accomplish more than the individual Projects could achieve alone.