BIOLOGICAL BASES OF ALCOHOLISM

项目摘要/摘要 这一博士后和博士后培训计划的首要目标是培养能够 进行从分子到认知/临床、生物学等层面的基础研究 酒精(乙醇)使用障碍的病因、治疗和预防的潜在机制。二十 俄勒冈健康与科学大学(OHSU)的研究生教员担任 OHSU行为学院两个研究生项目的博士后和博士后研究员 神经科学和神经科学研究生项目。主要研究兴趣代表共同的领域 兴趣，如乙醇反应和风险的遗传基础，已知和未获知的乙醇决定因素 酒精的奖赏、厌恶和神经病理效应的神经生物学基础， 与反复和/或发育性酒精暴露相关的神经适应机制 依赖和敏化，以及酒精对记忆、认知和社会行为的影响。此外, 与其他滥用药物的影响进行比较具有重大意义。技术战略体现在三个方面 分析层次：1.行为/认知/社会，2.Neurophysiological/neuropharmacological/systems， 细胞/分子/基因组生物学。波特兰酒精研究中心内的协调研究工作 酒精中毒综合神经科学倡议(INIA)和俄勒冈州国家灵长类动物 研究中心(ONPRC)通过统一调查人员和创建多维空间来加强培训 研究项目。培训包括坚实的基础科学、特定药理学的课程基础 在酒精和药物成瘾方面进行培训，并广泛和持续地参与研究。四名博士后 每年的受训者将由2-3年的培训补助金支持，然后由个人国家研究资助 服务奖或他们导师的资源。每年三名博士后实习生将得到 为期2年的培训补助金。我们有一个完善的计划，以改善我们受训人员的多样性和所有 学员还需要完成负责任的研究行为方面的初始强化课程 作为这一领域的继续教育。我们的实习生有很多机会参与公共活动 教育和外展。

Project Summary / Abstract The overarching aim of this pre- and post-doctoral training program is to develop specialists who are able to conduct basic research at levels ranging from the molecular to the cognitive/clinical, on the biological mechanisms underlying the etiology, treatment and prevention of alcohol (ethanol) use disorders. Twenty members of the graduate faculty of the Oregon Health & Science University (OHSU) serve as preceptors for predoctoral students and postdoctoral research fellows in two graduate programs at OHSU—Behavioral Neuroscience, and the Neuroscience Graduate Program. Major research interests represent areas of common interest, such as genetic bases for ethanol responses and risk, learned and unlearned determinants of ethanol reward, neurobiological bases for the rewarding, aversive and neuropathological effects of ethanol, neuroadaptive mechanisms associated with repeated and/or developmental ethanol exposure, ethanol dependence and sensitization, and effects of ethanol on memory, cognition and social behavior. In addition, comparison to the effects of other drugs of abuse is of significant interest. Technical strategies reflect three levels of analysis: I. Behavioral/cognitive/social, II. Neurophysiological/neuropharmacological/systems, III. Cellular/molecular/genomic biological. Coordinated research efforts within the Portland Alcohol Research Center (PARC), the Integrative Neuroscience Initiative on Alcoholism (INIA) and Oregon National Primate Research Center (ONPRC) have strengthened training by unifying investigators and creating multidimensional research projects. Training includes firm curricular grounding in the basic sciences, specific pharmacological training in ethanol and drug addiction, and extensive and continuous participation in research. Four predoctoral trainees per year will be supported by the training grant for 2-3 years, and then by individual National Research Service Awards or their mentors' resources. Three postdoctoral trainees per year will be supported by the training grant for 2 years. We have a well-developed plan for improving the diversity of our trainees and all trainees are expected to complete an initial intensive course in the Responsible Conduct of Research, as well as continuing education in this area. Ample opportunities exist for our trainees to be involved in public education and outreach.