UC Davis Chemical Biology Program

加州大学戴维斯分校化学生物学项目(CBP)的目标是提供有效的交叉培训 在化学/生物界面上为博士生预科。经过他们的CBP交叉训练， 这些学生将从传统上理解综合和分析工具的价值 在解决与生物途径、细胞、组织相关的问题时与化学有关 以及特别关注与人类健康有关的生物学问题的生物体。 加州大学戴维斯分校的化学生物学社区包括一大群多产的、资金充足的 以及合作的教职员工，他们有很强的指导博士生的历史。这个 CBP教员由29名培训员组成，他们在7个不同的部门担任主要职务 五所不同的学院。CBP教员研究项目涵盖了广泛的主题(例如 钙信号，糖生物学，代谢工程，DNA修复，RNA修饰， 翻译、光接收、光合作用、癌症治疗、药物代谢、 代谢组学、分子成像和基因组编辑)使用广泛的方法 (例如遗传学、基因组学、X射线结晶学、核磁共振光谱、电子顺磁共振光谱、质量 光谱学、组合化学、高通量筛选、计算模型、 酶学和有机合成)。实习生将从第一年起被选中参加这个项目 有兴趣在化学/生物专业开展论文研究的学生 来自五个不同研究生群体(化学、生物化学、分子、细胞和 发育生物学；生物医学工程；药理学和毒理学 生物物理学)。这些学生将从事交叉培训课程工作，交叉培训实验室 轮换，正在进行的研究报告，职业发展活动，负责 主持研究、培训和年度务虚会。这项提案要求支持六项 博士前学生时段，支持3-4名实习生，每次为期两年，通常是在第二年 以及第三年的博士培训。这一支持，以及主要的机构 加州大学戴维斯分校做出的承诺将建立一个博士前项目，将更有效地 让我们的受训人员为化学/生物领域的科学生涯做好准备。

The goal of the UC Davis Chemical Biology Program (CBP) is to provide effective cross training at the chemistry/biology interface for pre-doctoral candidates. After their CBP cross training, these students will understand the value of the synthesis and analysis tools traditionally associated with chemistry in addressing problems related to biological pathways, cells, tissues and organisms with a particular focus on biological questions related to human health. The chemical biology community at UC Davis includes a large group of productive, well funded and collaborative faculty members with a strong history of mentoring pre-doctoral students. The CBP faculty comprises 29 trainers with primary appointments in seven different departments in five different colleges. CBP faculty research programs cover a broad swath of topics (e.g. calcium signaling, glycobiology, metabolic engineering, DNA repair, RNA modification, translation, photoreception, photosynthesis, cancer therapeutics, drug metabolism, metabolomics, molecular imaging and genome editing) using an extensive range of approaches (e.g. genetics, genomics, x-ray crystallography, NMR spectroscopy, EPR spectroscopy, mass spectrometry, combinatorial chemistry, high throughput screening, computational modeling, enzymology and organic synthesis). Trainees will be selected for this program from first year students with an expressed interest in carrying out thesis research at the chemistry/biology interface from five different graduate groups (Chemistry; Biochemistry, Molecular, Cellular and Developmental Biology; Biomedical Engineering; Pharmacology and Toxicology and Biophysics). These students will engage in cross training coursework, cross training laboratory rotations, research-in-progress presentations, career development activities, responsible conduct in research training and annual retreats. This proposal requests support for six predoctoral student slots to support 3-4 trainees for two years each, typically during the second and third years of their PhD training. This support, along with the major institutional commitments made by UC Davis, will establish a predoctoral program that will more effectively prepare our trainees for scientific careers at the chemistry/biology interface.