Experimental Irradiators

项目摘要/摘要 实验辐射源共享资源(EISR)维护和运行电离源 西德尼·基梅尔综合癌症中心用于实验和临床前研究的放射 (SKCCC)成员。该资源支持DNA损伤、癌症生物学、辐射等领域的发现研究 使用细胞模型的生物学、免疫学以及临床前和转化性研究；异种移植、原位和 同基因肿瘤模型；先进的转基因小鼠癌症模型。已执行的服务 由资源人员提供的培训内容包括仪器的操作、向用户提供设计建议 实验、治疗计划(剂量学)和对用户进行新技术教育。资源员工 监督所有仪器的操作，协助用户并在必要时操作仪器，并进行 适当的仪器维护和维修。上的非成员也可以使用该资源 会员不使用时，以增加收费为基础。EISR资源包括平行对置双X射线 源系统、X射线源系统、图像引导正压小动物辐射研究 平台(SARRP)和两个Cs-137辐照器。位于SKCCC癌症研究中心的SARRP 二号楼，配备了机载锥束CT，以指导小动物的精确焦点照射， 模仿人类的放射治疗。SARRP最初代表着高度尖端的技术 在约翰·霍普金斯大学开发，并正在不断开发中，以结合分子光学 (生物发光和荧光)层析成像用于反应评估。这些进步为用户提供了 在与临床相关的模型系统中进行精确放射治疗和测试的无与伦比的机会 翻译。 SKCCC托管共享资源 报告期：2020年1月1日至2020年12月31日

PROJECT SUMMARY/ABSTRACT The Experimental Irradiators Shared Resource (EISR) maintains and operates sources of ionizing radiation for use in experimental and preclinical studies by Sidney Kimmel Comprehensive Cancer Center (SKCCC) Members. The resource supports discovery research in DNA damage, cancer biology, radiation biology, immunology and preclinical and translational research using cell models; xenograft, orthotopic and syngeneic tumor models; and advanced genetically modified mouse models of cancer. Services performed by the resource staff include training in the operation of the instruments, advising users on the design of experiments, treatment planning (dosimetry) and educating users on new technologies. Resource staff oversee all instrument operations, assist users and operate the instruments when necessary, and conduct appropriate instrument maintenance and repair. The resource is also available to nonmembers on an increased-fee basis when not in use by Members. EISR resources include a parallel-opposed dual X-ray source system, an X-ray source system, an image-guided orthovoltage small-animal radiation research platform (SARRP) and two Cs-137 irradiators. The SARRP, located in the SKCCC Cancer Research Building II, is equipped with onboard cone beam CT to guide precise focal irradiation of small animals, mimicking human radiation treatments. SARRP represents highly sophisticated technology initially developed at Johns Hopkins and is under continuous development to incorporate molecular optical (bioluminescence and fluorescence) tomography for response assessment. These advances offer users unparalleled opportunities for precision radiation treatments and testing in model systems relevant for clinical translation. SKCCC Managed Shared Resource Reporting Period: January 1, 2020 to December 31, 2020