Core C Clinical Core

项目摘要 临床核心（核心C） 位于美国南部腹地，在亚拉巴马和邻近各州的农村社区有着突出的地位， UAB CFAR临床核心（核心C）的独特定位是支持科学查询的接口， 预防和治疗、诊所和社区，通过以下具体目标加速消灭艾滋病毒/艾滋病： 1.提供计算机化数据库和信息服务，2。提供全面、高效的 标本库从特征明确的艾滋病毒感染者（PLWH）中获得，3.提供研究 协调服务，4。提供全面的生物统计和流行病学服务。核心 自成立以来，C一直是UAB CFAR的基石，UAB 1917艾滋病毒/艾滋病诊所（1917诊所） 作为它的焦点。作为一个学习型医疗保健系统，在临床护理点进行观察 推动了核心C支持的科学举措，与CFAR的总体使命保持一致， 1988.对知识的追求，以解决临床相关的问题，推动了发现和奖学金 反馈给1917诊所，以加强对PLWH的服务提供和治疗效果， 影响全国和全球。在过去5年的资助期间，核心C生成了780个分析就绪 数据集，处理了152，000个样本瓶，并采集了10，800例患者报告的结局调查 在护理点进行评估，同时支持70项校外赠款和发表300多份同行审查报告 手稿一个值得注意的里程碑，临床核心支持了来自UAB的12名早期研究者（ESI） 以及在上一个资助期内来自其他CFAR的10名ESI，他们共同获得了15 职业发展奖（包括11个K奖）和4个首届R01奖。 人口普查大约有3,500名艾滋病毒携带者，其中非洲裔美国人和男男性行为者不成比例， 1917诊所仍然是核心C的焦点。然而，临床核心领导力超越了1917年 诊所通过杰斐逊县艾滋病毒/艾滋病社区联盟培养独特的研究平台， 亚拉巴马质量管理小组，包括9个艾滋病毒诊所全州提供照顾超过6800 PLWH。核心C创新包括整合生物统计和流行病学服务， 协同作用和效率，推出一个用户友好的，基于网络的REDCap共同申请表，以征求任何 (or多个）核心服务，并增加了系统发育分析数据库和地理空间数据库， 宣传和加强艾滋病毒预防和治疗科学。核心C发挥着关键作用， CFAR之间的合作，为我们的跨学科研究提供重要的研究支持和领导 团体和新成立的消除亚拉巴马艾滋病毒科学工作组，并利用与其他 临床和转化科学中心（UAB CTSA）。最终，临床 核心使命是提供综合、全面的临床和转化研究服务 推进艾滋病毒预防和治疗科学，促进卫生公平，加速消灭艾滋病毒/艾滋病。

PROJECT SUMMARY Clinical Core (Core C) Situated in the Deep South, with prominent footing in rural communities in Alabama and adjacent states, the UAB CFAR Clinical Core (Core C) is uniquely positioned to support scientific inquiries at the interface of prevention and treatment, clinic and community, to hasten an end to HIV/AIDS via the following Specific Aims: 1. To provide Computerized Database and Informatics Services, 2. To provide a comprehensive and efficient Specimen Repository obtained from well-characterized persons living with HIV (PLWH), 3. To provide Study Coordination Services, and 4. To provide comprehensive Biostatistical and Epidemiological Services. Core C has been a cornerstone of the UAB CFAR since its inception, with the UAB 1917 HIV/AIDS Clinic (1917 Clinic) as its focal point. Functioning as a learning healthcare system, observations made at the point of clinical care have driven the scientific initiatives supported by Core C, aligned with the overarching CFAR mission, since 1988. The pursuit of knowledge to address clinically relevant questions has fueled discovery and scholarship that has fed back to the 1917 Clinic to enhance service delivery and treatment outcomes for PLWH, with broad impact nationally and globally. During the last 5-year funding period, Core C generated 780 analysis ready datasets, processed 152,000 specimen vials, and captured 10,800 patient reported outcomes survey assessments at the point of care, while supporting 70 extramural grants and publication of over 300 peer-review manuscripts. A noteworthy milestone, the Clinical Core supported 12 early stage investigators (ESI) from UAB and an additional 10 ESI from other CFARs during the last funding period, who were collectively awarded 15 career development awards (including 11 K awards) and 4 first R01 awards. With a census of roughly 3,500 PLWH, disproportionately African Americans and men who have sex with men, the 1917 Clinic remains the focal point of Core C. However, Clinical Core leadership extends beyond the 1917 Clinic to cultivate unique research platforms via the Jefferson County HIV/AIDS Community Coalition and Alabama Quality Management Group that includes nine HIV clinics statewide providing care for over 6,800 PLWH. Core C innovations include integration of Biostatistical and Epidemiological Services to facilitate synergies and efficiencies, roll out of a user-friendly, web-based REDCap Common Request Form to solicit any (or multiple) core services, and the addition of a Phylogenetic Analysis Database, and Geospatial Database to inform and augment HIV prevention and treatment science. Core C plays a pivotal role enhancing intra- and inter-CFAR collaborations, providing vital research support and leadership to our Interdisciplinary Research Groups and newly formed Ending HIV in Alabama Scientific Working Group, and leveraging synergies with other research Centers, notably the Center for Clinical and Translational Science (UAB CTSA). Ultimately, the Clinical Core mission is to provide ready access to integrated, comprehensive clinical and translational research services to advance HIV prevention and treatment science to promote health equity and hasten an end to HIV/AIDS.