Institutional Career Development Core

KL2导师临床学者计划吸引了一批才华横溢的初级教员 来自耶鲁大学的多个学科(医学院、护理学、公共卫生、文学院 以及科学、工程和应用科学)，他们将从事T1-T4翻译研究。这 该计划非常成功，吸引了151名学者，他们出版了5200种出版物， 一直是国家卫生研究院258项赠款的私人投资机构，总共获得了5.57亿美元的赠款资金。值得注意的是，99%的 我们的KL2学者曾在学术界、工业或公共卫生领域担任过职务，并经常与 负责临床和转化性研究的领导工作。我们的目标是在这一成功的基础上提供 接受个性化、基于能力的翻译研究培训的学者，为他们做好准备 促进学习型医疗保健系统，推进个性化健康，解决健康差距问题。 这种准备包括临床试验、大数据、机器学习、生物信息学、多学科 翻译研究、团队科学、实施科学和基于社区的参与性研究。它 还向他们介绍监管问题、生物伦理、良好的临床实践以及驱动严格性的因素， 透明度和可复制性。九龙仓第二期计划可促进 学者通过提供：1)在复杂多样的多学科研究中成功工作的机会 团队，2)获得高级导师和最近的临床学者的指导，3)行业外部资助， 公共卫生和监管机构，以及4)在赠款编写和多学科团队方面的强化培训 科学。为了监督这些多样化的、积极性很高的初级调查人员，我们有一个教育领导层 团队成员：1)在不同翻译研究领域工作的三位杰出的调查员导师；2)和 经验丰富的多元化官员，以及3)评估和动态重塑医学教育的专家 程序。这个领导团队使用了来自以前学者及其导师的反馈来增加新的计划 为已经成功的项目干杯。我们扩展了我们的逻辑模型，以实现社交网络分析 跟踪学者的活动，我们将扩展课程，包括一门新的课程。这门课将会 混合学者和TL-1受训人员，他们将在团队中工作，因为他们在 在各种领域，如大数据/机器学习、多样性和包容性，以及运营研究实验室。 有了这些已经很强大的课程，我们相信耶鲁大学指导了临床学者 该计划将非常适合培训T1-T4翻译研究领域的下一代领导者 将以减轻疾病负担和改善美国及周边地区健康的方式改变医疗保健 整个世界。九龙第二期发展计划的具体目标是： 目标1：耶鲁导师临床学者计划：提供一个由导师组成的项目 研究经验、课程安排和研讨会，旨在促进科学研究的兴起 有才华的青年T1-T4翻译科学家学者的独立性和职业发展。 目标2：耶鲁大学健康科学硕士项目：为那些没有 高级研究学位，加上额外的课程和学术活动，以获得硕士学位 健康科学(MHS)，以解决他们在科学准备研究生涯中的局限性。

The KL2 Mentored Clinical Scholars Program attracts a diverse group of highly talented junior faculty across multiple disciplines from across Yale University (Schools of Medicine, Nursing, Public Health, Faculty of Arts and Sciences, Engineering and Applied Science) who will pursue careers in T1-T4 translational research. This Program has been extremely successful, attracting 151 Scholars who have authored >5200 publications, have been PIs on 258 NIH grants, and have received a total of $557 million in grant funding. Remarkably, 99% of our KL2 Scholars have attained positions in academia, industry or public health conducting, and often with leadership responsibilities for, clinical and translational research. We aim to build on this success by providing Scholars with individualized, competency-based training in translational research that prepares them to contribute to the learning healthcare system, to advance personalized health, and to address health disparities. This preparation includes training in clinical trials, big data, machine learning, bioinformatics, multidisciplinary translational research, team science, implementation science and community-based participatory research. It also introduces them to regulatory issues, bioethics, Good Clinical Practices, and factors that drive rigor, transparency, and replicability. The KL2 promotes the development of relevant competencies among the Scholars by providing: 1) opportunities to work successfully in complex and diverse multidisciplinary research teams, 2) access to mentorship by senior mentors and recent Clinical Scholars, 3) externships in industry, public health and regulatory agencies, and 4) intensive training in grant-writing and in multidisciplinary team science. To oversee these diverse, highly motivated junior investigators, we have an educational leadership team of: 1) three outstanding investigator mentors who work in different areas of translational research, 2) an experienced Diversity Officer, and 3) an expert in evaluating and dynamically reshaping medical education programs. This leadership team has used feedback from prior Scholars and their mentors to add new initiatives to the already successful program. We expanded our logic model to implement social network analyses to track the activities of the Scholars, and we will expand the curriculum to include a new course. That course will mix Scholars and TL-1 trainees who will work in teams as they get formal training and peer mentoring in a variety of areas such as big data/machine learning, diversity and inclusion, and running a research laboratory. With these additions to an already strong curriculum, we believe that the Yale Mentored Clinical Scholars Program will be ideally positioned to train the next generation of leaders in T1-T4 translational research who will transform healthcare in ways that alleviate the burden of disease and improve health in the US and around the world. The Specific Aims of the KL2 are: Aim 1: The Yale Mentored Clinical Scholars Program: To provide a program comprised of a mentored research experience, coursework, and seminars that are intended to promote the emergence of scientific independence and the career development of talented young T1-T4 translational scientist Scholars. Aim 2: The Yale Masters in Health Science Program: To provide those M.D. Scholars who do not possess an advanced research degree with additional coursework and scholarly activities to qualify for a Masters in Health Science (MHS) to address limitations in their scientific preparation for a research career.