Forging Translational Glycobiologists: Intermeshing Glycoscience Training and Clinical Education

摘要 目前，很少有人能将临床医学放在糖科学的框架内， 反之亦然。弥合这种翻译鸿沟的关键是支持科学家的发展 必要的跨学科知识和经验，同时提供糖科学方面的培训 人类生物学教育，总体框架是对人类疾病和临床紧迫性的认识。 该应用程序通过首创多学科职业发展计划来满足这一需求 临床医学背景下的糖科学将造就一支“翻译糖生物学家”队伍， 受医学需要启发，将进行基于血糖科学的研究的个人。从根本上说，这 目标将通过为计划学者配备必要的智力背景和 糖科学方面的必要实验室技能，以及对临床问题的深入了解。对这件事 最后，我们将在有经验的血糖科学研究人员和临床医生之间建立合作伙伴关系 哈佛大学教学医院培养血糖科学原理和技术技能的学者培训计划 与临床知识和实践相结合。致力于此的首席调查人员的组合 Goal(Sackstein，Chaikof和Cummings博士)，以及聚集的教职员工和非凡的 医院资源，使这一计划成为翻译糖生物学职业发展的理想选择。通过 在设计上，该项目利用了布里格姆与妇女学院翻译研究的悠久传统 医院，贝丝以色列女执事医疗中心，马萨诸塞州总医院，波士顿 儿童医院、达纳-法伯癌症研究所以及大哈佛医学院 学校和哈佛大学。通过课程作业和研讨会，项目学者将获得血糖科学 在两个主要实验室环境中，伴随着技术知识和技能的发展而获得的知识 和研讨会。为了确保科学和临床两个领域的发展，每个项目学者 将由一名研究导师联合指导，进行以实验室为基础的以项目为导向的血糖科学培训和 以医院为基础的临床教育临床导师。此外，每个项目的奖学金获得者将有一个专门的 职业导师，将进一步支持学者向职业独立的过渡。学者 任期为两年(最长为三年)，我们预计将有十名学者参加。 资助期，四名学者为初级教职临床医生，六名为资深学者 博士后研究员。我们相信，这种独特的糖科学教育、实验室结合 指导、临床暴露和指导将启动一支生物医学研究队伍，将 加速血糖科学的发展，更重要的是，将创造所需的以血糖科学为基础的 将改变心肺、血液和睡眠障碍的临床护理的突破，以及许多人， 许多其他疾病。

ABSTRACT Currently there are very few individuals that can place clinical medicine within the framework of glycoscience, and vice versa. The key to bridging this translational chasm is to support the development of scientists with requisite interdisciplinary knowledge and experience by providing training in glycosciences concomitantly with education in human biology, altogether framed by an appreciation of human diseases and clinical urgency. This application addresses this need by pioneering a multi-disciplinary career development program in glycosciences within the context of clinical medicine that will create a cadre of “Translational Glycobiologists,” individuals who will perform glycoscience-based inquiry inspired by medical necessity. Fundamentally, this goal will be accomplished by equipping Program Scholars with the requisite intellectual background and the necessary lab skills in the glycosciences, together with an in-depth appreciation of clinical issues. To this end, we will build partnerships between experienced glycoscience researchers and clinicians within the Harvard teaching hospitals to nurture Program Scholar training in glycoscience principles and technical skills integrated with clinical knowledge and practice. The combination of Principal Investigators dedicated to this goal (Drs. Sackstein, Chaikof, and Cummings), together with the assembled faculty and the extraordinary hospital resources, makes this program ideal for career development in Translational Glycobiology. By design, the program capitalizes on the long tradition of translational research within the Brigham & Women’s Hospital, the Beth Israel Deaconess Medical Center, the Massachusetts General Hospital, the Boston Children’s Hospital, and the Dana-Farber Cancer Institute, as well as within the greater Harvard Medical School and Harvard University. Through coursework and seminars, Program Scholars will gain glycoscience knowledge with concomitant development of technical knowledge and skills in both primary laboratory settings and workshops. To ensure development across both scientific and clinical spectrums, each Program Scholar will be jointly mentored by a Research Mentor for lab-based project-oriented glycoscientific training and a Clinical Mentor for hospital-based clinical education. In addition, each Program Scholar will have a dedicated Career Mentor that will further support the Scholar transition towards career independence. Scholar appointments will be for two years (maximum three years), and we anticipate a total of ten Scholars over the duration of the funding period, with four Scholars being junior faculty clinicians and six Scholars being senior post-doctoral fellows. We believe that this unique combination of glycoscience education, laboratory instruction, clinical exposures, and mentoring will launch a cadre of biomedical investigators that will accelerate the growth of glycoscience, and, more importantly, will create needed glycoscience-based breakthroughs that will transform clinical care for disorders of heart, lung, blood, and sleep, and for many, many other diseases.