Research Support Core

摘要--研究支持核心 此核心支持中心助学金(P30)申请继续支持分析化学 实验室和行政部门共享核心基础设施，并支持试点项目核心。的总体目标 研究支持核心是为以下方面提供最先进的、设备齐全和人员配备齐全的实验室资源 加州大学旧金山分校和其他机构的药物滥用研究人员的参与项目。我们的合作者 全国各地都需要复杂的分析化学来测量药物的浓度，他们的 代谢物和生物标志物，以便开展他们的研究。目标是提供支持，即 响应构成科学项目的需求，随着这些项目的变化和发展。作为研究 优先事项的变化和新的发现，前沿研究需要发展新的 方法：研究方法。我们的实验室在分析方法和生物标志物开发方面拥有多年的经验， 配备了最先进的仪器，以及一支非常有经验的工作人员。开发所需的新方法 未来的协作研究是我们P30中心支持的一项主要活动。这个设施是一个成本- 有效共享实验室资源，增强和扩展目前研究人员的研究可能性 由美国国立卫生研究院或其他联邦或非联邦来源资助，以加深我们对人类精神活性药物的理解 使用、滥用和成瘾、其健康后果及其治疗管理。

ABSTRACT – RESEARCH SUPPORT CORE This Core Support Center Grant (P30) application requests continued support for an analytical chemistry laboratory and administrative shared core infrastructure, and support for a pilot project core. The overall aim of the Research Support Core is to provide a state-of-the-art, well equipped and staffed laboratory resource for the participating projects of drug abuse researchers at UCSF and at other institutions. Our collaborators throughout the country require sophisticated analytical chemistry to measure concentrations of drugs, their metabolites, and biomarkers in order to carry out their research. The objective is to provide support that is responsive to the needs of constituent scientific projects, as these projects change and evolve. As research priorities change and new discoveries are made, cutting-edge research requires the development of new methods. Our laboratory has many years experience in analytical method and biomarker development, is equipped with state-of-the-art instruments, and a very experienced staff. Developing new methods required for future collaborative research is a major activity that is supported by our P30 Center. This facility is a cost- effective shared laboratory resource that enhances and extends research possibilities of investigators currently funded by NIH or other federal or nonfederal sources to further our understanding of human psychoactive drug use, abuse and addiction, its health consequences and its treatment management.