Developmental Neuroimaging Core

发育神经影像学核心项目摘要 发育神经影像学核心（DNC）已经并将继续成为快速发展的组成部分。 我们对大脑在典型和非典型发育过程中的结构和功能的理解有所增长。的 DNC活动的广度包括通过最先进的临床前成像结合动物成像 通过大量的高端人体成像系统来实现设施和人体成像。DNC将提供国家- 最先进的神经影像学服务，以最大限度地提高中心研究人员对IDD研究的质量和影响， 优化成像作为预测和干预创新的转化工具的应用， 发展障碍，并提供一系列的咨询和分析服务，以帮助新的和早期的 阶段研究者将成像研究纳入他们的研究工作中。DNC将开发创新的 神经影像学方法，并使他们获得大型和不断增长的IDDRC@WUSTL研究者 社区DNC的具体目标是促进神经影像学的发展，具体目标如下：（1） 为IDDRC社区提供服务，促进磁共振成像和光学成像的使用。 临床前和临床研究中的成像技术。Subaim 1a：提供高质量、全面的 研究设计咨询，包括样本选择、受试者准备、技术建议、电源 与样本量、脑-行为基因数据关联和脑-环境数据关联相关的考虑。 Subaim 1b：为IDDRC研究者进行具有成本效益的数据采集，包括开发受试者 准备协议，规定采集参数，优化成像质量，并提供所有必要的 进行扫描的技术支持。Subaim 1c：提供数据处理、信息学和分析服务 以帮助整合成像数据与基因组，表型和环境数据。(2)追求技术 推动缺碘症研究的发展。Subaim 2a：开发和比较静息状态功能连接 啮齿动物的MRI方法和光学方法。Subaim 2b：优化临床MRI数据采集，以满足或 超越研究质量，以扩大其在研究表型分析中的应用。

Developmental Neuroimaging Core Project Summary The Developmental Neuroimaging Core (DNC) has been, and will continue to be, integral to the rapid growth in our understanding of the brain’s structure and function during typical and atypical development. The breadth of DNC activity includes the incorporation of animal imaging through a state-of-the-art preclinical imaging facility and human imaging through a plethora of high-end human imaging systems. The DNC will provide state- of-the art neuroimaging services to maximize the quality and impact of IDD research by Center investigators, to optimize the application of imaging as a translational tool for innovation in prediction and intervention of developmental disabilities, and to provide a range of consultative and analytic services to help new and early stage investigators incorporate imaging research into their research efforts. The DNC will develop innovative neuroimaging methodologies and make them accessible to the large and growing IDDRC@WUSTL investigator community. The Specific Aims of the DNC, which will accelerate advances in neuroimaging, are as follows: (1) To provide services to the IDDRC community that facilitate the use of magnetic resonance imaging and optical imaging techniques in both preclinical and clinical studies. Subaim 1a: Provide high-quality, comprehensive consultation for study design, including sample selection, subject preparation, technological advice, power considerations related to sample size, brain-behavior gene data linkage, and brain-environmental data linkage. Subaim 1b: Conduct cost-efficient data acquisition for IDDRC investigators, including developing subject preparation protocols, specifying acquisition parameters, optimizing imaging quality, and providing all necessary technical support for conducting the scan. Subaim 1c: Provide data processing, informatics, and analytic services to assist the integration of imaging data with genomic, phenotypic and environmental data. (2) Pursue technical developments to advance IDD research. Subaim 2a: Develop and compare resting state functional connectivity MRI methods with optical methods for rodents. Subaim 2b: Optimize clinical MRI data acquisition to meet or exceed research quality to expand its use for research phenotyping.