USC/UCLA Center on Biodemography and Population Health

概述摘要 南加州大学/加州大学洛杉矶分校生物人口学和人口健康中心(CBPH)代表着一个独特和高度 南加州大学戴维斯老年学学院成功合作 (南加州大学)和格芬医学院老年医学和老年学多校区项目 在加州大学洛杉矶分校(UCLA)，每一个都专注于研究和 教授关于衰老的知识。CBPH在推动以理论为基础的努力方面发挥着长期的领导作用 将生物测量纳入以人口为基础的研究，正在进行的开发和验证 生物测量方案，并从理论上推动了对生物机制的研究 社会、经济、心理、医疗和环境因素“深入内心”，影响 健康过程随年龄增长而变化。CBPH发展了独特的临床和实验室基础设施，并 试点项目，以增进对生物人口指标的理解和使用，增加可用于 人口研究，支持更可靠和有效的数据收集，跨越大量的国家和 国际调查，并在测量和验证方面取得进展，使人口调查能够 跟上衰老科学的科学进步。这个应用程序提出了一组活动 旨在(I)扩大和加强生物人口学领域的理论发展，以便我们专注于 反映分子和细胞过程的新一代生物标记物反映基本机制 (2)继续努力吸引新的和有前途的研究人员进入这一领域；和(3)加强我们的 中心在支持开发、验证、实施和传播新的和 更好的生物统计学测量方案。CBPH的具体目标将是：(1)支持和 促进生物人口学研究，了解影响人口健康的多种相互作用的因素 (特别侧重于通过以下途径扩大和加深我们对生物途径的理解 生命过程中的哪些经历和接触会影响健康的轨迹，以及这些影响是如何 可能因小组和环境而异)；(2)进一步发展活跃的生物人口研究社区 通过在学者网络中聘请有地位和有前途的初级研究人员，这些学者可以帮助 生物人口学研究；(3)为支持尖端生物人口学研究的试点项目提供资金； (4)支持开发和传播新的研究技术、方法和数据 行政核心的研究资源、传播核心和传播活动。这样的进步 需要支持人口健康模型的发展，这些模型提供了亟需的证据 政策规划者关于最有效的干预点，以改善人口健康和减少 健康差距。CBPH已经开发了基础设施、资源和专业知识来实现其 并继续在推进老龄化生物人口学研究方面发挥重要的领导作用。 OMB编号0925-0001/0002(08/12版批准至2015年8月31日)页面续格式页面

Overview Abstract The USC/UCLA Center on Biodemography and Population Health (CBPH) represents a unique and highly successful collaboration between the Davis School of Gerontology of the University of Southern California (USC) and the Multi-campus Program in Geriatric Medicine and Gerontology in the Geffen School of Medicine at the University of California at Los Angeles (UCLA), each of which focuses exclusively on research and teaching on aging. The CBPH has a longstanding role as a leader in efforts to promote theory-based integration of biological measurement into population-based studies, on-going development and validation of biological measurement protocols, and theoretically motivated research on the biological mechanisms by which social, economic, psychological, medical and environmental factors “get under the skin” to influence the process of health change with age. The CBPH has developed unique clinical and laboratory infrastructure and pilot projects to improve understanding and use of biodemographic indicators, increase indicators available to population studies, support more reliable and valid collection of data across a large number of national and international surveys, and made advances in measurement and validation that allow population surveys to keep pace with scientific advances in the science of aging. This application proposes a set of activities designed to (i) expand and enhance theoretical development of the field of biodemography so that we focus on a new generation of biomarkers reflecting molecular and cellular processes that reflect the basic mechanisms of aging, (ii) continue efforts to attract new and promising researchers to the field, and (iii) enhance our Center’s unique role in supporting development, validation, implementation and dissemination of new and better biodemographic measurement protocols. The specific aims of the CBPH will be to: (1) support and foster biodemographic research to understand the multiple and interacting factors that affect population health (with a particular focus on expanding and deepening our understanding of the biological pathways through which experiences and exposures over the life-course impact trajectories of health and how such influences may vary across subgroups and settings); (2) further develop an active biodemographic research community by engaging established and promising junior researchers in a network of scholars who can help advance biodemographic research; (3) offer funding for pilot projects to support cutting-edge biodemographic research; (4) support development and dissemination of new research technologies, methodologies and data through our Research Resource & Dissemination Core and dissemination activities of Administrative Core. Such advances are needed to support development of models of population health that provide much needed evidence for policy planners regarding the most effective points of intervention to improve population health and reduce health disparities. The CBPH has developed the infrastructure, resources and expertise to accomplish its goals and continue its significant leadership role in advancing biodemographic research on aging. OMB No. 0925-0001/0002 (Rev. 08/12 Approved Through 8/31/2015) Page Continuation Format Page