Training of the Pediatric Physician-Scientist

项目总结/摘要 这是儿科医生-科学家T32支持的第二次更新申请 华盛顿大学医学院的培训项目。儿科医生科学家玩 在促进改善儿童健康的知识方面发挥关键作用。为了满足国家持续的需求， 补充临床博士后研究金水平的儿科医生-科学家管道， 我们的计划每年为4名学者提供最多2名导师的职业发展途径。 多年来，通过利用华盛顿大学医学院内丰富的生物医学资源， 医学，我们的儿童健康研究中心和医疗中心校园。正如我们所做的， 在过去的15年里，我们计划的长期目标是培养学员， 通过应用基础和基础生物学的最新进展，对儿科疾病导向生物学进行研究 转化科学;如发育生物学，细胞生物学，免疫学，遗传学/基因组学， 和系统生物学。该提案的具体目标包括：1）受保护的指导研究 与成熟的调查人员的经验，涵盖了广泛的学科内， 华盛顿大学医学院和儿科系，必修 实验室管理，科学严谨性，统计学，granecraft， 负责任的研究行为，和生物医学信息学3）个性化的具体课程 根据学员的调查领域，4）持续反馈给学员，导师和 项目领导，以及5）女性和代表性不足的受训人员的发展 少数群体该计划，现在十五岁，有一个良好的记录，超过国家 基准（15年T到K的转换率= 52%;这个周期= 57%），并将最终关闭 基础/转化科学家和儿科临床医生之间的知识差距。加里A.西尔弗曼， 医学博士，博士担任项目主任，大卫亨斯塔德，医学博士。作为培训 导演学员将继续利用我们的机构资助的最先进的核心设施， 提供例如全基因组/外显子组DNA测序、生物信息学、冷冻EM成像， 基因组编辑和模型动物开发，以促进儿科疾病状态的研究。的 该计划的长期目标正在实现，因为它的学员有助于我们了解 人类发展疾病的未来几十年，而演变成下一代的 科学领导者，榜样和导师，为后代的儿科医生- 科学家

PROJECT SUMMARY / ABSTRACT This is the second renewal application for support of the Pediatric physician-scientist T32 training program at the Washington University School of Medicine. Pediatric physician-scientists play a crucial role in advancing knowledge that improves child health. To meet the ongoing national need to replenish the Pediatric physician-scientist pipeline at the clinical post-postdoctoral fellowship level, our program supports a mentored career development pathway for 4 Scholars per year for up to 2 years by leveraging a wealth of biomedical resources within the Washington University School of Medicine, our Child Health Research Center and the Medical Center campus. As we have done for the past 15 years, the long-term objective of our program is to develop Trainees that focus their research efforts on Pediatric disease-oriented biology by applying recent advances in the basic and translational sciences; such as developmental biology, cell biology, immunology, genetics/genomics, and systems biology. The specific aims of this proposal include: 1) protected mentored research experiences with well-established investigators encompassing a wide range of disciplines within the Washington University School of Medicine and the Department of Pediatrics, 2) obligatory educational programs in laboratory management, scientific rigor, statistics, grantsmanship, responsible conduct of research, and biomedical informatics 3) individualized specific coursework based on the Trainees’ areas of investigation, 4) continuous feedback to the Trainees, mentors and program leadership, and 5) the development of Trainees who are women and underrepresented minorities. The program, now fifteen years old, has an excellent track record by exceeding national benchmarks (15-year T to K conversion rate = 52%; this cycle = 57%), and will ultimately close the knowledge gap between basic/translational scientists and pediatric clinicians. Gary A. Silverman, M.D., Ph.D. serves as the Program Director, and David Hunstad, M.D. serves as the Training Director. The Trainees will continue to utilize our institutionally-funded state-of-art core facilities that provide, for example, whole genome/exome DNA sequencing, bioinformatics, cryo-EM imaging, genome editing and model animal development, to facilitate the study of Pediatric disease states. The long-term goals of this program are being realized as its Trainees contribute to our understanding of human developmental diseases for decades to come, while evolving into the next generation of scientific leaders, role models and mentors for subsequent generations of Pediatric physician- scientists.