Brief Research In Aging and Interdisciplinary Neurosciences (BRAIN)

项目总结 哥伦比亚大学医学中心的神经学系是多学科神经学研究的丰富场所，特别关注老化的神经系统和阿尔茨海默病及相关痴呆症(AD和ADRD)。这项提案寻求继续资助20名临床前学生每年夏天参加老龄化和跨学科神经科学(大脑)简短研究计划的职位。对于大脑项目，我们已经开发了一种全面的方法，为在生物医学、行为和临床研究领域发展职业生涯的博士前学生开发一个正式的研究项目。这项工作是通过为这些学生提供简短但密集的暑期研究培训经验来协作进行的。研究培训通过基础神经科学、神经病理学、神经遗传学、神经心理学、流行病学和临床试验领域的持续研究，提供基础、行为和临床研究的机会，重点是阿尔茨海默病和相关痴呆、衰老相关运动神经元疾病、中风和癫痫，以及治疗这些疾病患者的神经学临床试验。纳入神经疾病进展的生物和认知标记物的方法，如大脑淀粉样蛋白和tau蛋白，结构脑成像，以及记忆、执行功能和其他认知领域的评估，都嵌入了培训课程。此外，在紧张的研究经历过程中，将提供全面的结构化研究教育课程，主题包括良好的临床实践、基本研究方法、摘要作者介绍和海报演示、统计概念和分析方法的介绍，以及对阿尔茨海默病等最常见神经疾病的流行病学和病理生理学审查。我们学院在培养世界各地的学术神经学家方面拥有最强劲的记录，这一短期、密集的课程建立在丰富的资源基础上，通过实践介绍神经学研究，全面回顾研究原理，从而确保这些学生在包括阿尔茨海默病在内的老化神经系统疾病领域发展研究生涯的最佳机会。

Project summary The Department of Neurology at Columbia University Medical Center serves as a rich site for multidisciplinary neurological research, with particular focus on the aging nervous system and Alzheimer’s disease and Related Dementias (AD and ADRD). This proposal seeks to continue funding for positions for 20 preclinical students participating in the Brief Research in Aging and Interdisciplinary Neurosciences (BRAIN) program each summer. For the BRAIN program, we have developed a comprehensive approach to develop a formal research program for predoctoral students early in developing careers in biomedical, behavioral and clinical research. The work is collaboratively approached through brief but intensive mentored summer research training experiences for these students. The research training provides opportunities in basic, behavioral and clinical research through ongoing research in the fields of basic neuroscience, neuropathology, neurogenetics, neuropsychology, epidemiology, and clinical trials, with a focus on Alzheimer’s disease and Related Dementias, aging-related motor neuron disease, stroke, and epilepsy, as well as neurologic clinical trials treating patients with these disorders. Methods for inclusion of biological and cognitive markers of neurological disease progression, such as cerebral amyloid and tau, structural brain imaging, as well as assessment of memory, executive function, and other cognitive domains are embedded within the training curriculum. In addition, a comprehensive structured research education curriculum is delivered over the course of the intense research experience, with topics including good clinical practice, basic research methodologies, introductions to abstract authorship and poster presentations, and introduction of statistical concepts and approach to analyses, as well as epidemiologic and pathophysiologic reviews of the most common neurologic disorders such as Alzheimer’s disease. Our institution has the strongest track record of developing academic neurologists of anywhere worldwide, and this short-term, intense program builds upon this wealth of resources through hands-on introductions to neurological research, comprehensive review of principles of research, and thus assures the best opportunity for these students to develop research careers in the field of disorders of the aging nervous system including Alzheimer’s disease.