UC Davis Multi-Disciplinary Cancer Research Training Program to Advance Precision Cancer Prevention and Care in Latin America.

项目总结 卫生保健获得和感染控制的改善导致了低收入和低收入国家的预期寿命增加 拉丁美洲的中等收入国家。随着人口老龄化，拉丁美洲的癌症负担 已经大幅增加。到2030年，拉丁美洲预计每年平均新增癌症160万例 病例和100万人死于癌症。拉丁美洲柳叶刀肿瘤学委员会的一份报告强调了 来自该地区的临床前和临床肿瘤学研究的数量，作为控制癌症的限制 负担。哥伦比亚和秘鲁是拉丁美洲人口最多的两个国家，它们有 国家资助的国家癌症研究所(NCIS)，是癌症治疗参考中心，并领导 国家在癌症控制和护理方面的努力。然而，这些医院的癌症风险评估和患者治疗 机构主要基于北美和欧洲患者开发的工具。尽管有 杰出的研究人员和医生，拉丁美洲的大多数癌症中心缺乏培训计划 将使他们能够开发或调整适用于 来自该地区的个人的祖先或突变特征。目前的融资机会是理想的 旨在正规化和加强美国医疗研究人员和 哥伦比亚和秘鲁的供应商。它将为精确肿瘤学研究知识提供坚实的基础 转移和建立拉丁美洲发展精准癌症医学所需的当地人力资本。 基于我们在拉丁美洲人口统计学、癌症流行病学和 遗传学，NIH资助拉丁裔人群的癌症研究，以及研究合作的良好记录 以及与哥伦比亚和秘鲁研究人员的培训，加州大学戴维斯分校多学科的总体目标 推进拉丁美洲癌症精确预防和护理的癌症研究培训计划将： 1)加强哥伦比亚和秘鲁的精准癌症医学研究的当地能力 补充和解决当地培训计划中的差距并提供实践经验的课程 和支持与该区域有关的研究项目开发，2)提供研究方面的实践培训 资源开发，包括道德培训、生物库最佳做法和基于云的生物信息学；以及 3)为基础科学和临床方向的学期学员的指导性研究分配试点资金。我们 建议设立课程，以培养研究生和博士后/临床研究员的精确度 肿瘤学研究。我们将为学员做好准备，以便在本国实施和分享他们的新技能 并与美国的调查人员合作。我们将利用该计划之间的持续合作 哥伦比亚和秘鲁的首席研究人员、大学和NCIS，以确定相关的研究领域 可以通过培训计划来加强。

PROJECT SUMMARY Improvements in health care access and infection control have led to life expectancy increases in Low- and Middle-Income Countries (LMICs) in Latin America. As the population ages, the Latin American cancer burden has dramatically increased. By 2030, Latin America is expected to have annual averages of 1.6M new cancer cases and 1M cancer deaths. A Latin America Lancet Oncology Commission report highlighted the small amount of preclinical and clinical oncology research originating in the region as a limitation to control cancer burden. Colombia and Peru, the Latin American LMICs with the first and second largest populations, have state-funded national cancer institutes (NCIs) that are cancer treatment reference centers, and which lead national efforts in cancer control and care. However, cancer risk assessment and patient treatment at these institutions is primarily based on tools developed in North American and European patients. Despite having exceptional researchers and physicians, most cancer centers in Latin America lack training programs that would allow them to develop or adapt precision prevention or treatment tools that are appropriate to the ancestry or mutation profiles of individuals from the region. The current funding opportunity is the ideal program to formalize and enhance ongoing collaborations between US-based healthcare researchers and providers in Colombia and Peru. It will provide a solid foundation for precision oncology research knowledge transfer and to build local human capital necessary to develop precision cancer medicine in Latin America. Building on our extensive expertise on Latin American population demography, cancer epidemiology and genetics, NIH funded cancer studies in Latino populations, and a strong track record of research collaboration and training with Colombian and Peruvian researchers, the overall goals of the UC Davis Multidisciplinary Cancer Research Training Program to Advance Precision Cancer Prevention and Care in Latin America are to: 1) Enhance local capacity for precision cancer medicine research in Colombia and Peru by implementing a curriculum that complements and addresses gaps in local training programs and provides hands on experience and support for research project development relevant to the region, 2) Provide hands on training on research resource development including ethics training, biobanking best practices, and cloud-based bioinformatics; and 3) allocate pilot funding for mentored research for basic science and clinically-oriented term trainees. We propose to establish a curriculum to train graduate students and postdoctoral/clinical fellows in precision oncology research. We will prepare trainees to implement and share their new skills in their home countries and to collaborate with U.S-based investigators. We will leverage ongoing collaborations among the program Principal Investigators, universities, and NCIs of Colombia and Peru to identify relevant areas of research that could be enhanced by the training program.