Biological Mechanisms Core-RC-2

资源核心2(RC2)生物机制核心：项目摘要 确定脆弱和与年龄有关的脆弱性的原因仍然是 老年学研究。这一挑战的关键是更好地理解 导致脆弱的潜在生物学基础和确定关键的生物学途径 制定可能有助于预防或减轻脆弱和丧失独立性的干预措施。目标是 约翰霍普金斯老年美国人独立中心(OAIC)的生物机制核心(RC-2)是 支持下一代与脆弱相关的病因发现，并促进这些 发现临床相关的诊断、预防和治疗方式。这个核心实现了这一点 通过提供高质量的生物测量专业知识、技术和基础设施 实现这一目标所必需的。为了全面涵盖生物学和测量 作为研究虚弱相关病因学所需的专业知识，我们聘请了一支具有相当多经验的领导团队。 生物和翻译专业知识以及几名内部顾问，他们带来了至关重要的额外 专业知识、对学员的指导以及RC-2的基础设施。RC-2的具体目标是：1)提供 最先进的科学知识、基础设施和技术，以促进生物和 与脆弱有关的病因学研究，2)提供从人类受试者和从 验证与脆弱相关的假说所需的动物模型，3)促进生物学的翻译 对干预措施或预防为主的临床研究的发现，4)提供培训、指导和 向有前途的初级调查人员提供关于影响脆弱性的生物机制的指导，以及5)提供 与RC-2相关的科学和活动的机构和外部可见性。这些提高知名度的努力将是 由第8节描述的新的信息传播核心(IDC)进一步促进。我们的目标将 通过核心领导者和他们的实验室之间的密切沟通来实现，密切 与伊斯兰会议组织其他核心建立伙伴关系，并聘请专家顾问参与高度相关的 线粒体测量、代谢组学、小鼠模型开发、纳米技术 诊断目的，以及与药物开发有关的纳米技术。通过提供这些资源，RC-2 将促进高质量的研究，阐明与临床相关的生物学途径，这些途径是脆弱和 相关的干预措施有望减轻虚弱、相关疾病和丧失独立性。

Resource Core 2 (RC2) Biological Mechanisms Core: Project Summary The identification of the etiologies of frailty and age-related vulnerability remains a crucial challenge for gerontological research. Key to this challenge are the development of a better understanding of the underlying biological basis that contributes to frailty and the identification of key biological pathways for the development of interventions that might help prevent or alleviate frailty and loss of independence. The goal of Johns Hopkins Older Americans Independence Center (OAIC) Biological Mechanisms Core (RC-2) is to enable the next generation of frailty-related etiological discovery and to promote the translation of these discoveries into clinically relevant diagnostic, preventive, and treatment modalities. This core achieves this through the provision of high-quality biological measurement expertise, technologies, and infrastructure necessary to attain this goal. In order to comprehensively encompass the biological and measurement expertise necessary to study frailty-related etiology, we have engaged a leadership team with considerable biological and translational expertise as well as several internal consultants who bring crucial additional expertise, mentorship for trainees, and infrastructure to RC-2. The specific aims of RC-2 are to: 1) provide state of the art scientific expertise, infrastructure, and technology necessary to advance biological and etiological research related to frailty, 2) provide access to biological samples from human subjects and from animal models necessary to test hypotheses related to frailty, 3) facilitate the translation of biological findings into interventions or prevention-focused clinical studies, 4) provide training, mentorship, and guidance to promising junior investigators around biological mechanisms that impact frailty, and 5) provide institutional and external visibility for RC-2 related science and activities. These visibility efforts will be further facilitated by a novel Information Dissemination Core (IDC) as described in section 8. Our aims will be accomplished through close communication between the core leaders and their laboratories, close partnership with the other OAIC cores, and the engagement of expert consultants in the highly relevant areas of mitochondrial measurement, metabolomics, mouse model development, nanotechnologies for diagnostic purposes, and nanotechnology related to drug development. By providing these resources, RC-2 will foster high quality research that elucidates clinically relevant biological pathways that underlie frailty and related interventions that hold promise to attenuate frailty, related conditions, and the loss of independence.