Geriatrics Research: From Bench-to-Bedside

项目总结/摘要 弹性，定义为对压力源的反应能力，随着年龄的增长和老年人的共病情况而下降。 有机体到目前为止，在提高我们对衰老恢复力的理解方面几乎没有取得进展， 它的多成分维度在应对身体，认知和社会压力，部分原因是 复原力本身可能是一个动态的多系统过程，在压力条件下最为明显。这 申请是一个为期五年的合作会议补助金，以继续成功的“老年医学研究： 从实验室到床边”系列。该系列产生了巨大的影响。过去的会议 “范式转换”的时刻和“关键”的交界处，如脆弱，多发性硬化和谵妄。这里 我们建议建立桥梁，将恢复力科学家和来自物理，认知， 和社会领域讨论，辩论，并相互学习的动态多成分现象， resilience.在第一次会议上，弹性世界概述：科学现状，我们将重点关注 设置阶段，并讨论从物理，认知和心理社会领域的弹性工作定义。 一个目标是确定共同点和不同点，以及我们如何能够实施一个共同的 因此，我们需要对“复原力”这一概念进行适当的界定，以便在不同的情况下对“复原力”进行适当的量化。在第二次会议上， 压力测试和弹性的生物标志物，我们的目的是讨论弹性压力测试范式， 可能与弹性结果相关的分子标记。在第一次会议上， 会议将提及复原力和复原力成果的可操作定义，承认 不同领域和背景下的定义可能略有不同。最后，第三次会议题为优化 Resilience.通过整合前两次会议建立的基础，我们将侧重于干预措施， 优化老年人的复原力。这一系列会议，一旦完成，将作为一个论坛和一个 统一的线索，将汇集国家研究领导人建立一个综合的多层面 了解更古老生物体的复原力。

PROJECT SUMMARY/ABSTRACT Resilience, defined as the ability to respond to stressors, declines with age and co-morbid conditions in older organisms. To date, little progress has been made to improve our understanding of resilience with aging and its multi-component dimensions in response to physical, cognitive, and social stressors, in part because resilience itself is likely a dynamic multi-systemic process that is most evident under conditions of stress. This application is for a five-year cooperative conference grant to continue the successful “Geriatrics Research: Bench-to-Bedside” series. The series has had an outstanding impact. Past conferences represented “paradigm-shifting” moments and “pivotal” junctures in areas such as frailty, multimorbidity, and delirium. Here we propose to build bridges and bring together resilience scientists and experts from the physical, cognitive, and social domains to discuss, debate, and learn from each other the dynamic multi-component phenomena of resilience. In the first conference, Overview of the Resilience World: State of the Science, we will focus on setting the stage and discuss working definitions of resilience from physical, cognitive, and psychosocial fields. A goal will be to identify areas of commonalities and differences and how we can operationalize a shared concept so that “resilience” can be quantified appropriately in different contexts. In the second conference, Stress tests and Biomarkers of Resilience, we aim to discuss resilience stress test paradigms and molecular markers that may be associated with resilient outcomes. Building on the first conference, this conference will refer to operationalized definitions of resilience and resilient outcomes, acknowledging that definitions may differ slightly across fields and contexts. Lastly, the third conference is entitled Optimizing Resilience. By integrating the foundation built in the first two conferences, we will focus on interventions to optimize resilience in older adults. This conference series, once completed, will serve as a forum and a unifying thread that will bring together national research leaders to build an integrative multidimensional understanding of resilience in older organisms.