Geriatrics Research: From Bench-to-Bedside

项目摘要/摘要 韧性，被定义为对压力源的反应能力，随着年龄的增长和老年患者的共病情况而下降 有机体。到目前为止，在提高我们对衰老和弹性的理解方面进展甚微。 它的多成分维度对身体、认知和社会压力的反应，部分原因是 恢复力本身可能是一个动态的多系统过程，在压力条件下表现得最为明显。这 申请为期五年的合作会议补助金，以继续成功的“老年医学研究： 从板凳到床边“系列。这部系列剧产生了突出的影响。过去的会议代表 虚弱、多发病和精神错乱等领域的“范式转换”时刻和“关键”时刻。这里 我们建议搭建桥梁，并将来自身体、认知、 和社交领域讨论、辩论和相互学习动态的多组件现象 恢复力。在第一次会议上，弹性世界概述：科学状况，我们将重点关注 从生理、认知和心理社会三个方面为弹性做好准备，并讨论弹性的工作定义。 目标将是确定共同点和不同之处，以及我们如何能够实施共享的 概念，以便在不同的情况下能够适当地量化“复原力”。在第二次会议上， 压力测试和弹性的生物标志物，我们的目标是讨论弹性压力测试范例和 可能与恢复力结果相关的分子标记。在第一届会议的基础上，这 会议将提及复原力和复原力成果的可操作性定义，承认 不同的字段和上下文的定义可能略有不同。最后，第三次会议的题目是优化 恢复力。通过整合前两届会议建立的基础，我们将专注于干预 优化老年人的复原力。这一系列会议一旦完成，将成为一个论坛和 统一思路，将国家研究领先者聚集在一起，构建一体化的多维 了解老生物体的复原力。

PROJECT SUMMARY/ABSTRACT Resilience, defined as the ability to respond to stressors, declines with age and co-morbid conditions in older organisms. To date, little progress has been made to improve our understanding of resilience with aging and its multi-component dimensions in response to physical, cognitive, and social stressors, in part because resilience itself is likely a dynamic multi-systemic process that is most evident under conditions of stress. This application is for a five-year cooperative conference grant to continue the successful “Geriatrics Research: Bench-to-Bedside” series. The series has had an outstanding impact. Past conferences represented “paradigm-shifting” moments and “pivotal” junctures in areas such as frailty, multimorbidity, and delirium. Here we propose to build bridges and bring together resilience scientists and experts from the physical, cognitive, and social domains to discuss, debate, and learn from each other the dynamic multi-component phenomena of resilience. In the first conference, Overview of the Resilience World: State of the Science, we will focus on setting the stage and discuss working definitions of resilience from physical, cognitive, and psychosocial fields. A goal will be to identify areas of commonalities and differences and how we can operationalize a shared concept so that “resilience” can be quantified appropriately in different contexts. In the second conference, Stress tests and Biomarkers of Resilience, we aim to discuss resilience stress test paradigms and molecular markers that may be associated with resilient outcomes. Building on the first conference, this conference will refer to operationalized definitions of resilience and resilient outcomes, acknowledging that definitions may differ slightly across fields and contexts. Lastly, the third conference is entitled Optimizing Resilience. By integrating the foundation built in the first two conferences, we will focus on interventions to optimize resilience in older adults. This conference series, once completed, will serve as a forum and a unifying thread that will bring together national research leaders to build an integrative multidimensional understanding of resilience in older organisms.