Geriatrics Research: From Bench-to-Bedside

项目概要/摘要 复原力，定义为应对压力源的能力，随着年龄的增长和老年人的共病状况而下降 有机体。迄今为止，在提高我们对衰老和恢复能力的理解方面进展甚微。 其对身体、认知和社会压力源的多成分维度的反应，部分原因是 复原力本身可能是一个动态的多系统过程，在压力条件下最为明显。这个 申请为期五年的合作会议拨款，以继续成功的“老年病学研究： “从工作台到床边”系列。该系列产生了显着的影响。过去的会议代表 虚弱、多病和谵妄等领域的“范式转变”时刻和“关键”时刻。这里 我们建议搭建桥梁，将来自身体、认知、 和社会领域讨论、辩论和相互学习动态的多成分现象 弹性。在第一次会议“复原力世界概述：科学现状”中，我们将重点关注 搭建舞台并讨论身体、认知和社会心理领域复原力的工作定义。 我们的目标是确定共同点和差异点，以及我们如何实施共同的 概念，以便可以在不同的情况下适当地量化“弹性”。在第二次会议上， 压力测试和复原力生物标志物，我们的目标是讨论复原力压力测试范式和 可能与弹性结果相关的分子标记。在第一次会议的基础上，本次 会议将提及复原力和复原力成果的可操作定义，并承认 不同领域和上下文的定义可能略有不同。最后，第三次会议的标题是优化 韧性。通过整合前两次会议所建立的基础，我们将重点关注以下方面的干预措施： 优化老年人的复原力。该系列会议一旦完成，将作为一个论坛和 统一主线，将汇集国家研究领导者，建立一个综合的多维 了解古老生物体的恢复能力。

PROJECT SUMMARY/ABSTRACT Resilience, defined as the ability to respond to stressors, declines with age and co-morbid conditions in older organisms. To date, little progress has been made to improve our understanding of resilience with aging and its multi-component dimensions in response to physical, cognitive, and social stressors, in part because resilience itself is likely a dynamic multi-systemic process that is most evident under conditions of stress. This application is for a five-year cooperative conference grant to continue the successful “Geriatrics Research: Bench-to-Bedside” series. The series has had an outstanding impact. Past conferences represented “paradigm-shifting” moments and “pivotal” junctures in areas such as frailty, multimorbidity, and delirium. Here we propose to build bridges and bring together resilience scientists and experts from the physical, cognitive, and social domains to discuss, debate, and learn from each other the dynamic multi-component phenomena of resilience. In the first conference, Overview of the Resilience World: State of the Science, we will focus on setting the stage and discuss working definitions of resilience from physical, cognitive, and psychosocial fields. A goal will be to identify areas of commonalities and differences and how we can operationalize a shared concept so that “resilience” can be quantified appropriately in different contexts. In the second conference, Stress tests and Biomarkers of Resilience, we aim to discuss resilience stress test paradigms and molecular markers that may be associated with resilient outcomes. Building on the first conference, this conference will refer to operationalized definitions of resilience and resilient outcomes, acknowledging that definitions may differ slightly across fields and contexts. Lastly, the third conference is entitled Optimizing Resilience. By integrating the foundation built in the first two conferences, we will focus on interventions to optimize resilience in older adults. This conference series, once completed, will serve as a forum and a unifying thread that will bring together national research leaders to build an integrative multidimensional understanding of resilience in older organisms.