Geriatrics Research: From Bench-to-Bedside

老年病学研究：从实验室到临床

• 批准号: 10237641
• 负责人: Peter M. Abadir
• 金额: $ 1.87万
• 依托单位: AMERICAN GERIATRICS SOCIETY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10237641
• 关键词: Age; Aging; American; Area; Biological Markers; Biology; Biology of Aging; Chronic; Clinical; Clinical Research; Cognitive; Collaborations; Communities; Delirium; Development; Dimensions; Disease; Education; Elderly; Faculty; Fostering; Foundations; Geriatrics; Geroscience; Goals; Grant; Health; Individual; Inflammation; Institutes; Interest Group; Intervention; Journals; Knowledge; Leadership; Learning; Measurement; Medical Students; Mentorship; Minority; Minority Participation; Mission; Names; National Institute on Aging; Nature; Older Population; Organism; Outcome; Physicians; Process; Publications; Research; Research Personnel; Science; Scientist; Series; Societies; Stress; Stress Tests; Structure; Syndrome; Time; TimeLine; Training; Translating; Translations; United States; United States National Institutes of Health; Vision; age related; bench to bedside; clinical care; comorbidity; frailty; improved; interest; meetings; member; molecular marker; multidisciplinary; multiple chronic conditions; nutrition; psychosocial; research and development; resilience; response; social; social stressor; stress resilience; stressor; symposium

PROJECT SUMMARY/ABSTRACT Resilience, defined as the ability to respond to stressors, declines with age and co-morbid conditions in older organisms. To date, little progress has been made to improve our understanding of resilience with aging and its multi-component dimensions in response to physical, cognitive, and social stressors, in part because resilience itself is likely a dynamic multi-systemic process that is most evident under conditions of stress. This application is for a five-year cooperative conference grant to continue the successful “Geriatrics Research: Bench-to-Bedside” series. The series has had an outstanding impact. Past conferences represented “paradigm-shifting” moments and “pivotal” junctures in areas such as frailty, multimorbidity, and delirium. Here we propose to build bridges and bring together resilience scientists and experts from the physical, cognitive, and social domains to discuss, debate, and learn from each other the dynamic multi-component phenomena of resilience. In the first conference, Overview of the Resilience World: State of the Science, we will focus on setting the stage and discuss working definitions of resilience from physical, cognitive, and psychosocial fields. A goal will be to identify areas of commonalities and differences and how we can operationalize a shared concept so that “resilience” can be quantified appropriately in different contexts. In the second conference, Stress tests and Biomarkers of Resilience, we aim to discuss resilience stress test paradigms and molecular markers that may be associated with resilient outcomes. Building on the first conference, this conference will refer to operationalized definitions of resilience and resilient outcomes, acknowledging that definitions may differ slightly across fields and contexts. Lastly, the third conference is entitled Optimizing Resilience. By integrating the foundation built in the first two conferences, we will focus on interventions to optimize resilience in older adults. This conference series, once completed, will serve as a forum and a unifying thread that will bring together national research leaders to build an integrative multidimensional understanding of resilience in older organisms.

项目摘要/摘要 弹性，定义为对压力源的反应能力，随着年龄的增长和合并状况而下降 有机体。迄今为止，几乎没有取得进步来提高我们对衰老和 它响应身体，认知和社会压力源的多组分维度，部分原因是 弹性本身可能是一个动态的多系统过程，这是压力条件下的大多数证据。 申请是为期五年的合作会议赠款，以继续成功的“老年医学研究： 板凳对床头”系列。该系列产生了出色的影响。过去的会议代表 在脆弱，多种疾病和del妄等领域，“范式转移”的时刻和“关键”关头。这里 我们建议建造桥梁，并将弹性科学家和专家汇集在一起 和社会领域，讨论，辩论和学习的动态多组分现象 弹力。在第一次会议，《弹性世界：科学状态》的概述中，我们将重点关注 设置舞台和讨论的工作定义，从身体，认知和社会心理领域进行弹性。 目标是确定共同点和差异领域，以及我们如何运作共享 概念，以便可以在不同的情况下适当地量化“弹性”。在第二次会议中 压力测试和弹性的生物标志物，我们旨在讨论弹性应力测试范例和 可能与弹性结局相关的分子标记。在第一次会议上建立这个 会议将涉及对弹性和弹性结果的操作定义，并承认 定义可能在各个字段和上下文之间略有不同。最后，第三次会议标题为优化 弹力。通过整合前两个会议中建立的基础，我们将专注于干预措施 优化老年人的弹性。该会议系列完成后，将作为论坛和一个 统一的线程将使国家研究领导者聚集在一起，建立一个综合的多维 了解老年生物的弹性。