Utilizing Technology and AI Approaches to Facilitate Independence and Resilience in Older Adults

美国65岁以上的成年人口将从5410万增长到9470万 2060年，这种人口结构的转变将伴随着痴呆症的大幅增加。 普遍性。越来越多的文献支持睡眠障碍与认知功能之间的关键联系。 减值和下降。睡眠不好，特别是慢波振荡减少， 发生在非快速眼动（NREM）慢波睡眠（SWS），正在研究， 可能的干预措施。在SWS期间，白天编码的记忆痕迹是 重新激活，加强，并从海马转移到新皮层，在那里他们 变得更加持久的长期记忆。因此，SWS显示出作为目标的希望， 旨在调节AD病理生理学和减缓甚至预防AD的治疗。内 根据这项提议，我们正在开发一种可穿戴技术， 成年人在舒适的家中。我们的数字治疗仪采用EEG头带， 闭环神经刺激以增强慢波睡眠期间的大脑活动。通过调整这个 技术，以满足老年人的独特需求，并包装复杂的传感器，电路， 和算法到一个舒适的头带，我们正在把这个实验室技术转化为一个 无障碍治疗

The U.S. population of adults aged ≥65 years will grow from 54.1 to 94.7 million by the year 2060 and this demographic shift will be accompanied by a substantial increase in dementia prevalence. A growing literature supports a critical link between sleep disturbance and cognitive impairment and decline. Poor sleep, specifically decrements in the slow-wave oscillations that occur during non-rapid eye movement (NREM) slow-wave sleep (SWS), are being studied as possible points of intervention. During SWS, memory traces encoded during the day are reactivated, strengthened, and transferred from the hippocampus to the neocortex, where they become more durable, long-term memories. Thus, SWS shows promise as a target for therapies aimed at modulating AD pathophysiology and slowing or even preventing AD. Within this proposal, we are developing a wearable technology that slows cognitive decline in older adults in the comfort of their own homes. Our digital therapeutic employs an EEG headband and closed-loop neurostimulation to enhance brain activity during slow wave sleep. By adapting this technology to the unique needs of older adults and packaging the complex sensors, circuitry, and algorithms into a comfortable headband, we are translating this laboratory technique into an accessible therapy.