Utilizing Technology and AI Approaches to Facilitate Independence and Resilience in Older Adults

美国65岁以上成年人口每年将从54.1万人增至9470万人 到 2060 年，这种人口变化将伴随着痴呆症的大幅增加 流行率。越来越多的文献支持睡眠障碍和认知能力之间的关键联系 损害和衰退。睡眠质量差，特别是慢波振荡的减少 发生在非快速眼动 (NREM) 慢波睡眠 (SWS) 期间，正在研究为 可能的干预点。在SWS期间，白天编码的记忆痕迹是 重新激活、强化并从海马体转移到新皮质，在那里它们 成为更持久、更长期的记忆。因此，SWS 显示出作为目标的希望 旨在调节 AD 病理生理学并减缓甚至预防 AD 的疗法。内 根据这项提案，我们正在开发一种可穿戴技术，可以减缓老年人的认知能力下降 成年人在自己舒适的家中。我们的数字治疗仪采用脑电图头带和 闭环神经刺激可增强慢波睡眠期间的大脑活动。通过调整这个 技术满足老年人的独特需求，并封装了复杂的传感器、电路、 和算法到舒适的头带中，我们正在将这种实验室技术转化为 易于接受的治疗。

The U.S. population of adults aged ≥65 years will grow from 54.1 to 94.7 million by the year 2060 and this demographic shift will be accompanied by a substantial increase in dementia prevalence. A growing literature supports a critical link between sleep disturbance and cognitive impairment and decline. Poor sleep, specifically decrements in the slow-wave oscillations that occur during non-rapid eye movement (NREM) slow-wave sleep (SWS), are being studied as possible points of intervention. During SWS, memory traces encoded during the day are reactivated, strengthened, and transferred from the hippocampus to the neocortex, where they become more durable, long-term memories. Thus, SWS shows promise as a target for therapies aimed at modulating AD pathophysiology and slowing or even preventing AD. Within this proposal, we are developing a wearable technology that slows cognitive decline in older adults in the comfort of their own homes. Our digital therapeutic employs an EEG headband and closed-loop neurostimulation to enhance brain activity during slow wave sleep. By adapting this technology to the unique needs of older adults and packaging the complex sensors, circuitry, and algorithms into a comfortable headband, we are translating this laboratory technique into an accessible therapy.