Network on Education, Biosocial Pathways, and Dementia across Diverse Populations

项目总结 尽管阿尔茨海默病和相关痴呆症(ADRD)的发病率很高，但我们还没有发展 可以显著减缓或逆转痴呆症进程的临床干预措施。最强大的国家之一 对ADRD的决定因素，即教育程度，仍然知之甚少。推进科学认识 关于教育如何、为什么和谁与ADRD有关，我们建议建立一个ADRD的跨学科网络 他们的共同专业知识对于实现NIA缩小ADRD教育差距的目标至关重要： 人口健康科学家，凭借他们在塑造痴呆症风险和韧性的行为方面的专业知识，以及 ADRD研究人员凭借他们在ADRD生物学和神经认知方面的专业知识。我们的网络将 通过探索教育与ADRD差距的关系，促进对教育如何相关的科学理解 形成韧性和风险的社会经济、社会、心理和生物机制，如果这些 模式因种族和民族而异。需要确定和澄清机制，以便为干预措施提供信息 缩小ADRD的教育差距。NIH资助的基于人口的纵向研究形成了 链接到此网络的核心数据资源和网络的领导力非常适合满足更广泛的 科学目标。我们将通过建立跨学科网络来促进教育和ADRD科学 新的、新兴的和成熟的ADRD科学家将应用尖端方法和技术 从他们各自的学科回答关于教育和ADRD关系的复杂问题。我们的 网络将通过年度会议、小型会议促进研究协作和专业发展 工作组、试点奖项和研讨会。年度会议和工作组将为新的 和新兴的ADRD学者，与现有的ADRD学者开展跨学科的合作 边界和试点奖励将支持合作研究项目。研讨会将提供介绍性的 ADRD科学方面的培训和赠款撰写方面的专业发展，以及科学传播。我们会 向科学和更广泛的政策社区传播网络产品，这些产品可发现并 用户界面友好。我们将开发一个网络网页和社交媒体账户来分享录制的网络研讨会， 网络开发的工具和用户指南，征求试点项目，并突出我们网络成员的工作 通过信息图表和简短的数据简报。该网络将由一个跨学科领导小组领导，该小组将 在支持该网络的数据、人口健康差距以及临床和生物学方面的专业知识 ADRD的基础，从而将社会、临床和ADRD科学以及关键的三个节点联系起来 为建立我们的网络：ADRD、教育和多样化的人口。我们的网络将发展出新的和新兴的 ADRD学者，迅速将他们融入该领域，并促进和提升他们的奖学金，使其具有高和 对教育和ADRD的持续影响。

PROJECT SUMMARY Despite the high prevalence of Alzheimer’s Disease and Related Dementias (ADRD), we have yet to develop clinical interventions that can substantially slow or reverse the course of dementia. One of the most powerful determinants of ADRD, educational attainment, remains poorly understood. To advance scientific understanding of how, why, and for whom education relates to ADRD, we propose to build an interdisciplinary network of ADRD scientists whose joint expertise is vital to achieving NIA’s goal to reduce educational disparities in ADRD: population health scientists, with their expertise in the behaviors that shape dementia risk and resilience, and ADRD researchers, with their expertise in the biology and neurocognitive aspects of ADRD. Our Network will advance scientific understanding of how education relates to ADRD disparities by exploring the socioeconomic, social, psychological, and biological mechanisms that shape resilience and risk and if these patterns differ by race and ethnicity. Identifying and clarifying mechanisms is needed to inform interventions to reduce educational disparities in ADRD. The NIH-funded longitudinal population-based studies that form the core data resources linked to this network, and the Network’s leadership, are well suited to meet the broader scientific aim. We will advance education and ADRD science by establishing an interdisciplinary Network of new, emerging, and established ADRD scientists who will apply cutting-edge methods and techniques from their respective disciplines to answer complex questions about the education—ADRD relationship. Our Network will facilitate research collaboration and professional development via annual meetings, small working groups, pilot awards, and workshops. Annual meetings and working groups will provide venues for new and emerging ADRD scholars to develop collaborations with established ADRD scholars across disciplinary boundaries and pilot awards will support collaborative research projects. Workshops will provide introductory training in ADRD science and professional development in grant writing, and science communication. We will disseminate Network products to the scientific and broader policy community that are discoverable and user-friendly. We will develop a Network webpage and social media accounts to share recorded webinars, Network-developed tools and user guides, solicit pilot projects, and highlight the work of our Network members through infographics and short data briefs. The Network will be led by an interdisciplinary leadership team with expertise in the data that undergirds the Network, population health disparities, and the clinical and biological underpinnings of ADRD, thus bridging the social, clinical, and ADRD sciences, as well as the three nodes critical to building our Network: ADRD, education, and diverse populations. Our Network will develop new and emerging ADRD scholars, quickly integrate them into the field, and facilitate and elevate their scholarship to have high and sustained impact in education and ADRD.