Effect of vibration on muscle properties, physical activity and balance in children with cerebral palsy

项目摘要/摘要 脑性瘫痪(CP)是一种神经肌肉疾病，在美国西南部约有80万人受到影响 肌肉体积、力量和质量、平衡不良和有限的体力活动是重要的。 对患有慢性支气管炎的儿童的担忧，因为他们与慢性病的高风险密切相关。因此， 确定解决这些问题的有效治疗策略势在必行。一种治疗方法已经重新- 高频、低幅度振动(HLV)引起了人们的极大关注。然而，研究考察了 HLV对脑性瘫痪患儿肌肉发育、平衡和体力活动的影响尚不明显。我们的长- 学期目标是确定降低慢性胰腺炎儿童慢性病风险的治疗方法。总体目标 这项应用的目的是确定每日HLV治疗对肌肉体积、力量和质量的影响，如 脑性瘫痪患儿的体力活动和平衡能力。我们的中心假设是每天的HLV 治疗将增加腿部肌肉体积和力量，减少腿部肌肉内脂肪，增加体力活动 改善脑性瘫痪患儿的平衡能力。为了验证中心假设，我们将追求以下目标：1) 确定每日HLV治疗对非卧床儿童肌肉体积和肌力的影响 2)确定每日HLV治疗对患有CP的门诊儿童肌肉质量的影响；3) 确定每日HLV治疗对患有CP的门诊儿童的体力活动的影响；以及4) 确定每日HLV治疗对患有CP的门诊儿童平衡的影响。一个随机化的骗局。 将使用一个治疗臂的拖车试验来实现这些目标。肌肉体积和肌内脂肪 将使用磁共振成像对腿部进行评估。腿部足底屈肌的肌肉力量将 使用测功机进行评估。体力活动将使用活动监测器进行评估。平衡将是 使用站立姿势摆动的测量以及跌倒恢复测试进行评估。将对HLV进行管理 每日10分钟，疗程6个月。这项拟议的研究具有重要意义，因为患有CP的儿童有瘦小、虚弱和肥胖- 肌肉浸润性、平衡性差和体力活动不足，这些都使他们处于患慢性病的高风险 疾病。我们提出了一种利用HLV和肌肉道具的综合评估的创新干预方法- 脑性瘫痪儿童的直立、平衡和体力活动。我们希望确定HLV能增加肌肉 脑性瘫痪儿童的大小、力量和素质、体力活动和平衡。研究的结果将会有一个 积极的影响，因为它们将是建立HLV作为治疗的有效性的关键一步 与慢性支气管炎儿童慢性病的高风险作斗争。

PROJECT SUMMARY/ABSTRACT Cerebral palsy (CP) is a neuromuscular disorder that affects approximately 800,000 individuals in the U.S. Low muscle volume, strength and quality, poor balance and limited participation in physical activity are significant concerns in children with CP because they are strongly linked to their high risk of chronic disease. Therefore, identifying effective treatment strategies that address these issues is imperative. One treatment that has re- ceived significant attention is high-frequency, low-magnitude vibration (HLV). However, studies examining the effect of HLV on muscle development, balance and physical activity in children with CP are lacking. Our long- term goal is to identify treatments that reduce the risk of chronic disease in children with CP. The overall objective of this application is to determine the effect of a daily HLV treatment on muscle volume, strength, and quality, as well as physical activity and balance in ambulatory children with CP. Our central hypothesis is that a daily HLV treatment will increase leg muscle volume and strength, reduce leg intramuscular fat, increase physical activity and improve balance in children with CP. To test the central hypothesis, we will pursue the following aims: 1) to determine the effect of a daily HLV treatment on muscle volume and muscle strength in ambulatory children with CP; 2) to determine the effect of a daily HLV treatment on muscle quality in ambulatory children with CP; 3) to determine the effect of a daily HLV treatment on physical activity in ambulatory children with CP; and 4) to determine the effect of a daily HLV treatment on balance in ambulatory children with CP. A randomized con- trolled trial with one treatment arm will be used to accomplish the aims. Muscle volume and intramuscular fat in the leg will be assessed using magnetic resonance imaging. Muscle strength of the leg plantar flexors will be assessed using a dynamometer. Physical activity will be assessed using activity monitors. Balance will be assessed using measures of standing postural sway, as well as tests of fall recovery. HLV will be administered 10 min/d for 6 months. The proposed study is significant because children with CP have small, weak and fat- infiltrated muscles, poor balance and low physical activity which places them at a high risk for developing chronic disease. We propose an innovative intervention utilizing HLV and a comprehensive assessment of muscle prop- erties, balance and physical activity in children with CP. We expect to determine that HLV increases muscle size, strength and quality, physical activity and balance in children with CP. The results of the study will have a positive impact as they will serve as a key step toward establishing the effectiveness of HLV as treatment to combat the high risk of chronic disease in children with CP.