Waisman Center Intellectual and Developmental Disabilities Research Center

我们寻求韦斯曼中心智力和发育障碍研究中心的持续支持， 一项全面的跨学科计划，重点是跨越生物、行为和生物医学的缺乏症 科学。Waisman IDDRC汇集了来自威斯康星大学麦迪逊分校24个学术部门的60名PI 医学与公共卫生学院，兽医学院，农业与生命科学学院，文学与科学学院， 教育、工程、社会工作和人类生态学。此应用程序请求支持 行政核心(核心A)，提供科学的领导、计划和教师发展、促进 跨学科协作、培训计划监督、生物统计学和生物信息学专业知识；以及 传播知识和最佳做法；以及三项创新的科学核心服务：临床 翻译(核心B)，在招募人类参与者方面提供服务、资源和培训， 临床研究协调/导航、临床评估、行为方法开发和生产 用于临床试验的临床级生物疗法；脑成像(核心C)，提供访问状态- 用于人类和动物研究的最先进的神经成像仪器(3T MRI、PET和MicroPET扫描仪 用于人类、非人灵长类和啮齿动物扫描、fNIRS和EEG记录系统)，以及 图像获取和分析的专门知识和工具；以及IDD模型(核心D)，提供资源、专门知识、 以及细胞和分子神经科学的技术服务，人类基因的产生和操纵 人多能干细胞(HPSC)系的建立及其传代和行为研究 突变或基因工程品系的小鼠和大鼠作为IDD条件模型的表型。此外, 我们请求支持一项研究项目，该项目旨在解决有关ADHD出现的一个基本问题 ASD儿童的症状，使用结合神经行为能力的多学科方法， 脑成像、统计基因组学和机器学习分析。 我们建议为由44名私人投资主任领导的69个研究项目提供核心支援，这些项目涉及三大主题 与IDD有关：1)神经发育和机制，2)神经系统紊乱，3)评估 和干预措施。韦斯曼中心IDDRC的核心服务和研究项目将共同 鼓励新的跨学科IDD研究，加强现有的IDD调查，重点放在 发现、预防和治疗IDD疾病，并改善患有IDD的患者的生活质量 IDD和他们的家人。

We seek continued support of the Waisman Center Intellectual and Developmental Disabilities Research Center, a comprehensive interdisciplinary program focused on IDD spanning the biological, behavioral, and biomedical sciences. The Waisman IDDRC brings together 60 PIs from 24 academic departments from the UW-Madison’s Schools of Medicine and Public Health, Veterinary Medicine, Agriculture and Life Sciences, Letters and Science, Education, Engineering, Social Work, and Human Ecology. This application requests support for an Administrative Core (Core A), providing scientific leadership, program and faculty development, facilitation of interdisciplinary collaboration, oversight of training programs, biostatistical and bioinformatics expertise; and dissemination of knowledges and best practices; and three innovative scientific core services: Clinical Translational (Core B), providing services, resources, and training in the recruitment of human participants, clinical research coordination/navigation, clinical assessment, behavioral methods development, and production of clinical grade biotherapeutics for use in clinical trials; Brain Imaging (Core C), providing access to state-of- the-art neuroimaging instrumentation for both human and animal studies (3T MRI, PET, and microPET scanners for human, non-human primate, and rodent scanning, an fNIRS, and an EEG recording system), as well as expertise and tools for image acquisition and analysis; and IDD Models (Core D), providing resources, expertise, and technical services in cellular and molecular neuroscience, the generation and manipulation of human pluripotent stem cell (hPSC) lines from humans with IDD conditions, as well as the generation and behavioral phenotyping of mutant or genetically engineered strains of mice and rats as models of IDD conditions. In addition, we request support for a Research Project that addresses a fundamental question on the emergence of ADHD symptoms in children with ASD, using a multidisciplinary approach that combines the power of neurobehavioral, brain imaging, statistical genomics, and machine learning analyses. We propose to provide core support to 69 research projects headed by 44 PIs addressing three broad themes relevant to IDD: 1) neurodevelopment and mechanisms, 2) disorders of the nervous system, and 3) assessments and interventions. Collectively the core services and the research project of the Waisman Center IDDRC will stimulate new interdisciplinary IDD research and enhance existing IDD investigations, with a sharp focus on discovery, prevention, and treatment for IDD conditions, and improvement of the quality of life of individuals with IDD and their families.