PAS GRAS: DE-RISKING METABOLIC, ENVIRONMENTAL AND BEHAVIORAL DETERMINANTS OF OBESITY IN CHILDREN, ADOLESCENTS AND YOUNG ADULTS

PAS Gras旨在预防和扭转四个年龄段的肥胖和相关代谢并发症：青春期前儿童(3-9岁)、青少年(10-18岁)、年轻人(19-25岁)和成年人(25-55岁)。Pas Gras专注于四个主要支柱。1)开发个性化风险评估工具(RAT)：一种算法，它将预测关键年龄组中肥胖的启动和发展，并识别随后几年特定并发症的风险因素，这将构成介入研究的新结果。2)制定和实施以大鼠为基础的个性化干预措施，将包括地中海饮食成分在内的非药理学生活方式改变单独或与合理的药物靶向代谢和神经内分泌机制相结合。3)通过共同制作创造性和交互式数字工具(包括简化版本的RAT)以及个性化饮食和体力活动计划，有效地让目标群体了解肥胖的原因、风险和干预措施。4)通过与医疗保健中心、学校、体育俱乐部、市政当局和其他相关行为者和公共当局制定健康和食品/营养扫盲和体育活动的联合方案，扩大和巩固整个欧洲的Pas Gras运动。PAS GRAS的成果将有助于欧盟在2050年之前将成年人超重/肥胖率降低15%，儿童/青少年超重/肥胖率降低30%，有助于下游减少肥胖相关并发症、药物和手术干预，并促进地中海饮食作为更有营养和可持续的未来的工具。Pas Gras是一个独特的多学科交叉研究团队，来自8个国家，包括12所顶尖大学和研究机构。非学术合作伙伴包括一个民间组织、一个公司、一个患者组织和一个泛欧洲研究会。

PAS GRAS aims to prevent and reverse obesity and associated metabolic complications in four age groups: pre-pubertal children (3-9 yr), adolescents (10-18 yr), young adults (19-25 yr), and adults (25-55). PAS GRAS focuses on four main pillars. 1) Develop a personalized risk assessment tool (RAT): an algorithm that will anticipate obesity priming and development in the critical age groups, and identify risk factors for specific complications in subsequent years that will constitute new outcomes for interventional studies. 2) Develop and implement RAT-based personalized interventions by integrating non-pharmacological lifestyle modifications including Mediterranean Diet components alone or with rational pharmacological targeting metabolic and neuroendocrine mechanisms. 3) Inform and engage effectively target groups on obesity causes, risks and intervention by co-production of creative and interactive digital tools (including a simpler version of the RAT) and personalized diet and physical activity programs. 4) Expand and consolidate the PAS GRAS tailor-made campaign across Europe through developing joint programs for health and food/nutrition literacy and physical activity, with healthcare centres, schools, sports clubs, municipalities, and other relevant actors and public authorities. PAS GRAS outcomes will contribute to a long-term 15% decrease in overweight/obesity prevalence in adults and 30% in children/adolescents in the EU until 2050, contributing to a downstream reduction of obesity-associated complications, pharmaceutical and surgical interventions, and to promote Mediterranean Diet as tool for a more nutritious and sustainable future. PAS GRAS is a unique multi- and interdisciplinary research team from 8 countries, including 12 top-level Universities and Research Institutions. Non-academic partners include a civil organization, one company, one patient organization and one Pan-European research Society.