Core F: Biostatistics and Bioinformatics

项目摘要/摘要 生物统计和生物信息学(Bios)核心(核心F)为CFAR成员提供了访问高度 合格的教职员工团队(核心成员)，他们是以团队为基础的科学领域的专家关键角色。这个 组建和部署这个团队的目标是响应传统的生物统计学和生物信息学 CFAR成员的服务需求，同时保持在开发和 使用最先进的方法解决现代统计设计和分析方面的挑战 临床、基础、转化、社会和行为流行病学研究。Bios核心增强了 CFAR成员通过合作和协商进行的艾滋病毒相关研究的影响和严谨性， 以及通过培训和辅导活动，强调新员工的职业发展 调查人员。2016年实施的创新的Bios核心联络系统在目前已经成熟 资助期，以促进目标Bios核心教职员工与所有科学核心和 科学工作组成员。Core提供一整套服务，可为 提案制定、研究设计、数据分析计划、案例报告表格和数据库设计，以及 科学研究的出版。在下一个项目期，Bios Core将继续优先考虑 艾滋病毒研究人员通过与发展核心的试点赠款计划和 临床研究核心，以支持提案开发和有效使用基于注册的数据。同时 随着时间的推移，我们将促进和加强与CFAR现有成员的长期合作，以促进 创新和有影响力的团队科学。Bios核心将把其活动集中在以下具体目标上： 目标1：向CFAR成员提供高质量的协作支持，特别强调支持 并加强早期艾滋病毒调查人员的建议； 目标2：利用核心成员的专业知识支持Emory CFAR的总体任务，以 在跨学科研究方面发展长期和自给自足的科学合作； 目标3：通过旨在促进和促进区域合作伙伴关系的接触活动，加强区域合作论坛之间和内部的协同作用 传播创新和有效的艾滋病毒相关研究方法和做法； 目标4：提拔下一代Bios教员担任核心领导职位，并聘用有才华的学员 确保核心继续长期成功地通过健全和 尖端生物统计学和生物信息学方法。

PROJECT SUMMARY/ABSTRACT The Biostatistics and Bioinformatics (Bios) Core (Core F) provides CFAR Members with access to a highly qualified team of faculty and staff (core members) who are expert key players in team-based science. The goals for populating and deploying this team are to respond to the traditional biostatistical and bioinformatic service needs of CFAR Members, while maintaining capacity for innovation in terms of developing and employing cutting edge methodology toward statistical design and analytic challenges that arise in modern clinical, basic, translational, and social and behavioral epidemiologic research. The Bios Core enhances the impact and rigor of HIV-related research conducted by CFAR Members through collaboration and consultation, as well as through training and mentorship activities that emphasize the career development of new investigators. An innovative Bios Core Liaison system, implemented in 2016, has matured over the current funding period to facilitate the linking of targeted Bios Core faculty members with all science Cores and Scientific Working Group members. The Core offers a complete suite of services that provide support for proposal development, study design, data analytic plans, case report form and database design, and the publication of scientific research. In the next project period, the Bios Core will continue to prioritize emerging HIV researchers through its collaborations with the Developmental Core's pilot grant programs and with the Clinical Research Core to support proposal development and effective use of registry-based data. At the same time, we will foster and strengthen long-term collaborations with established CFAR Members to promote innovative and impactful team science. The Bios Core will focus its activities on the following Specific Aims: Aim 1: Deliver high quality collaborative support to CFAR Members, with particular emphasis on supporting and enhancing the proposals of early-stage HIV investigators; Aim 2: Leverage Core members' specialized expertise in support of the Emory CFAR's overall mission, to develop long-term and self-sustaining scientific collaborations in transdisciplinary research; Aim 3: Enhance both inter- and intra-CFAR synergy through engagement activities designed to promote and disseminate innovative and impactful HIV-related research methods and practice; Aim 4: Promote the next generation of Bios faculty to Core leadership positions and engage talented trainees to ensure the Core's continued long-term success in enhancing CFAR Members' research through sound and cutting edge biostatistical and bioinformatics methodology.