Critical Analysis of a Rapid 4-compartment Model in Hispanic Adults:Effect of Age and Level of Body Fatness

摘要 为了响应PAR-16-439，支持竞争性研究（SCORE）试点项目奖（SC 1），PI是 提出了一项旨在系统评价不同样本中快速4室（4C）模型的研究 西班牙裔成年人。测试将包括一次对德克萨斯A&M运动生理学实验室的访问 国际大学。PI将招募18-79岁的西班牙裔男性（n = 150）和女性（n = 150）， 德克萨斯州的拉雷多进行这项研究。参与者将被区组招募，以确保年龄，性别和BMI的平等分布 组 标准4C模型将使用氧化氘测定全身水分（TBW），双能X射线 骨矿物质含量（BMC）的吸收测定法（DXA）和身体体积（BV）的水下称重。快速 4C模型将使用DXA（BV和BMC）和生物阻抗分析（BIA）（TBW）来确定。DXA- PI（1）最近在一组年轻西班牙裔成年人（18-45岁）中开发的推导出的BV方程将是 用于计算快速4C模型的BV。将通过比较%脂肪、脂肪量（FM） 快速4C模型与标准4C模型的去脂质量（FFM）。 还将测量FFM密度（DFFM）、骨矿物质（MoFFM）、全身水分（TBWFFM）和残留量（RFFM）。 在快速和标准4C模型中计算，并与Brozek等人的尸体参考值进行比较 al.（二）、PI最近透露，年轻和中年西班牙裔成年人（18-55岁）的FFM特征 年龄）显著不同于Brozek等人（2）的非西班牙裔白人和尸体参考值。这是一 由于Brozek等人（2）的尸体参考值用于独立方法，因此这是一项重要发现 如BIA。然而，需要进一步评价，以确定实况调查团的特征是否存在差异 在年龄和身体肥胖程度不同的西班牙裔成年人中。总的来说，拟议研究的结果 将有助于确定快速4C模型是否可用于西班牙裔成年人的多样化样本，以及是否 违反了独立评估（如BIA（73% TBWFFM））中采用的假设。

ABSTRACT In response to PAR-16-439, Support of Competitive Research (SCORE) Pilot Project Award (SC1), the PI is proposing a study that seeks to systematically evaluate a rapid 4-compartment (4C) model in a diverse sample of Hispanic adults. Testing will consist of one visit to the Exercise Physiology Laboratory at Texas A&M International University. The PI will recruit Hispanic men (n = 150) and women (n = 150) ages 18-79 years in Laredo Texas for this study. Participants will be block recruited to ensure equal distribution of age, sex, and BMI groups. A criterion 4C model will be determined using deuterium oxide for total body water (TBW), dual energy X-ray absorptiometry (DXA) for bone mineral content (BMC), and underwater weighing for body volume (BV). A rapid 4C model will be determined using DXA for BV and BMC and bioimpedance analysis (BIA) for TBW. The DXA- derived BV equation recently developed by the PI (1) in a group of young Hispanic adults (18-45 years) will be utilized to compute BV for the rapid 4C model. Validity will be established by comparing the %Fat, fat mass (FM), and fat-free mass (FFM) of the rapid 4C model against the criterion 4C model. The FFM density, (DFFM), bone mineral (MoFFM), total body water (TBWFFM), and residual (RFFM) will also be calculated in the rapid and criterion 4C model and compared against the cadaver reference values of Brozek et al. (2). The PI recently revealed that the FFM characteristics of young- and middle-aged Hispanic adults (18-55 years) significantly differs from non-Hispanic Whites and cadaver reference values of Brozek et al. (2). This is a significant finding since the cadaver reference values of Brozek et al. (2) are employed in stand-alone methods such as BIA. Nonetheless, further evaluations need to establish whether variations in FFM characteristics exist among Hispanic adults who vary in age and level of body fatness. Collectively, findings from the proposed study will help establish whether a rapid 4C model can be used in a diverse sample of Hispanic adults and whether the assumptions employed in stand-alone assessments such as BIA (73% TBWFFM) are violated.