NHGRI Sample Repository for Human Genetic Research

项目摘要 由NHGRI赞助并于2006年在Coriell研究所建立的NHGRI样本库， 人类遗传研究提供了一个可供使用的、集中的、具有良好特征的资源， 来自全球广泛人群的生物标本，包括1000个基因组计划的收集， 用于生物医学研究。NHGRI知识库的目标是促进和促进研究 人类遗传和基因组变异的建立，维护和分发高质量， 可再生的、可再现的、良好表征的和广泛同意的细胞系和DNA。NHGRI资源库 是一个全球性的资源，已被成千上万的研究人员用来支持无数的研究。 自成立以来，已向世界各地分发了20多万个细胞系、DNA和RNA样本， 世界上50个国家的研究人员，以及数千篇科学文章的研究结果， 使用这些样本和相关数据。建议的NHGRI知识库活动包括：（1）维护 清点和分发NHGRI储存库细胞系和现有储存库收集的DNA样品， (2)分发定制制剂和大量DNA、高分子量（HMW）DNA、RNA、细胞团，以及 根据科学界的要求定制板和面板，（3）扩大储存库， 人类泛基因组参考联盟提交的生物标本，并创建了一个新的小组， 诱导多能干细胞，将包括广泛的基因组变异，以满足日益增长的需求 研究界的，和（4）维护一个全面和安全的数据库和公共在线目录 为NHGRI知识库活动，并通过科学研究， 演讲、会议、教育活动和社区报告。50多年来，美国国立卫生研究院赞助的 凭借生物库的专业知识，Coriell是唯一有资格实现这些目标并战略性地扩大业务的公司。 和NHGRI存储库的产品。NHGRI知识库的目标与NHGRI的 使命是支持加速基因组研究的资源和技术开发。科利尔是一个 值得信赖的NIH合作伙伴，拥有确保成功运营的基础设施、专业知识和跟踪记录， 这一重要而独特的基因组资源的维持和生长。

PROJECT SUMMARY Sponsored by the NHGRI and established at the Coriell Institute in 2006, the NHGRI Sample Repository for Human Genetic Research provides a publically accessible, and centralized resource of well-characterized biospecimens from a wide range of global human populations, including the 1000 Genomes Project collection, for use in biomedical research. The objectives of the NHGRI Repository are to stimulate and facilitate the study of human genetic and genomic variation by establishing, maintaining, and distributing a repository of high-quality, renewable, reproducible, well-characterized, and broadly consented cell lines and DNA. The NHGRI Repository is a global resource that has been used by thousands of investigators to support countless research studies. Since its inception, over two hundred thousand cell lines, DNA and RNA samples have been distributed to researchers in 50 countries around the world, and thousands of scientific articles have resulted from studies using these samples and associated data. Proposed NHGRI Repository activities include: (1) maintaining inventory and distributing NHGRI Repository cell lines and DNA samples for the existing repository collection, (2) distributing custom preparations and lots of DNA, High Molecular Weight (HMW) DNA, RNA, cell pellets, and custom plates and panels as requested by the scientific community, (3) expanding the repository to include biospecimen submissions from the Human Pangenome Reference Consortium and creating a new panel of induced pluripotent stem cells that will encompass a wide range of genomic variation to meet the growing needs of the research community, and (4) maintaining a comprehensive and secure database and public online catalog for NHGRI Repository activities, and engaging the scientific community and public at large through scientific presentations, conferences, educational events, and community reports. With over 50 years of NIH-sponsored biobanking expertise, Coriell is uniquely qualified to achieve these aims and strategically expand the operations and offerings of the NHGRI Repository. The goals of the NHGRI Repository are consistent with the NHGRI’s mission to support development of resources and technology that accelerate genomic research. Coriell is a trusted NIH partner and has the infrastructure, expertise, and track-record to ensure the successful operations, maintenance and growth of this important and unique genomic resource.