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中文摘要
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摘要 纪念斯隆-凯特琳癌症中心发展研究计划(DRP)的目标 白血病孢子将为试点项目提供种子资金,这些项目显示出有潜力使 白血病的预防、诊断和/或治疗进展。在机构资金的补充下,DRP 将为有才华的研究人员或研究团队提供一到两年的资金,从临床和/或基础 来自MSK社区、邻近机构的科学背景,或支持与 其他白血病孢子。我们将每年邀请候选人提交研究建议,供同行评议。 白血病和转化性癌症研究专家委员会。我们将优先考虑以下研究建议 描述高风险/高回报假设驱动的工作,这些工作有可能推动 白血病研究,或将激动人心的协作团队聚集在一起的提案,这些团队将解决正在进行的 使用新的方法和技术解决白血病领域的问题。差饷物业估价署拨款申请者应 拥有医学博士和/或博士学位,并应拥有独立研究员的教员身份或 他们所在机构的临床研究员/研究科学家。申请者应证明有明确的 致力于白血病相关的转化性癌症研究。DRP调查员将被视为满员 白血病中MSK孢子的成员,并将参加正在进行的会议和研究研讨会 (白血病工作组、白血病疾病管理小组、 关注的血液恶性肿瘤科学中心)以及专门的孢子会议(年度、多年 机构孢子务虚会;孢子研讨会系列;每月进展会议)。DRP项目将是 由执行委员会在每月进度会议上监测,并将进行审查以评价 在当前或即将到来的赠款周期中,有可能成长为一个完整的孢子研究项目。《DRP》 致力于遵守和支持MSK政策和程序,以促进多样性和 加强妇女和代表人数不足的少数群体个人的参与。
英文摘要
ABSTRACT The goal of the Developmental Research Program (DRP) of the Memorial Sloan Kettering Cancer Center Leukemia SPORE is to provide seed funding for pilot projects that show potential to make meaningful advances in leukemia prevention, diagnosis, and/or treatment. Supplemented by institutional funds, the DRP will provide one to two years of funding to talented investigators or research teams from clinical and/or basic science backgrounds from the MSK community, neighboring institutions, or in support of collaborations with other Leukemia SPOREs. We will invite candidates annually to submit research proposals for peer-review by a committee of experts in leukemia and translational cancer research. We will prioritize research proposals that describe high-risk/high-reward hypothesis-driven work that has the potential to advance new avenues of leukemia investigation, or proposals that bring together exciting collaborative teams who will address ongoing problems in the leukemia field using new approaches and technologies. Applicants for DRP funding should possess an MD and/or PhD degree and should hold independent-investigator status as a faculty member or clinical researcher/research scientist at their institution. Applicants should have demonstrated a clear commitment to translational cancer research related to leukemia. The DRP investigators will be considered full members of the MSK SPORE in Leukemia and will participate ongoing meetings and research seminars (regular meetings and seminars held by the Leukemia Working Group, Leukemia Disease Management Team, Center of Hematologic Malignancies Science in Focus) as well as specialized SPORE meetings (annual, multi- institutional SPORE Retreat; SPORE Seminar Series; monthly progress meetings). The DRP projects will be monitored by the Executive Committee at monthly progress meetings, and will be reviewed to evaluate potential to grow into a full SPORE research project in the current or upcoming grant cycle. The DRP is committed to adhering to and supporting the MSK policies and procedures to promote diversity and strengthen the participation of women and individuals from underrepresented minorities.
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Assessing the Interplay Between Inflammatory Signaling and Epigenetic Dysregulation in Age-associated Clonal Hematopoiesis and Leukemia Initiation
  • 批准号:
    10291637
  • 项目类别:
  • 资助金额:
    $53.8万
  • 财政年份:
    2021
  • 负责人:
    Ross L Levine
  • 依托单位:
Assessing the Interplay Between Inflammatory Signaling and Epigenetic Dysregulation in Age-associated Clonal Hematopoiesis and Leukemia Initiation
  • 批准号:
    10659254
  • 项目类别:
  • 资助金额:
    $51.55万
  • 财政年份:
    2021
  • 负责人:
    Ross L Levine
  • 依托单位:
Assessing the Interplay Between Inflammatory Signaling and Epigenetic Dysregulation in Age-associated Clonal Hematopoiesis and Leukemia Initiation
  • 批准号:
    10488271
  • 项目类别:
  • 资助金额:
    $51.81万
  • 财政年份:
    2021
  • 负责人:
    Ross L Levine
  • 依托单位:
Project 1: Increasing therapeutic efficacy in isocitrate dehydrongenase (IDH)–mutant acute myeloid leukemia (AML)
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