INSIGHT: Integrated Models for the Development and Assessment of High Impact Chemicals and Materials

安全和可持续的设计(SSBD)化学品和材料对于应对现代社会的挑战至关重要。然而，缺乏利益攸关方的协调，相关数据的获取有限，以及缺乏标准化的方法，迄今阻碍了对SSBD采取全面办法的出现。Insight将通过开发化学品/材料的机械影响评估的创新框架来克服这些挑战。洞察框架将由集成数据、模型和影响结果路径(IOP)图的多层方法组成。Insight还将提供经过策划和用户友好的公平数据和计算模型/工作流程。Insight旨在促进化学品和材料的可持续性和安全性评估的范式转变，从支离破碎的情况转变为整体和综合的方法。Insight将提供决策地图，作为其综合框架的一部分，指导用户完成决策过程，协助他们以更有效和更全面的方式评估化学品/材料的社会、经济、健康和环境影响。Insight项目完全符合欧盟的安全和可持续发展原则以及欧洲绿色协议。Insight将支持制定中立、生物多样性保护、公共卫生和循环经济等领域的政策，从而帮助发展尊重整个地球的充满活力的经济，避免对人类和环境造成伤害。通过将尖端人工智能方法的使用民主化到SSBD，Insight将推动创新，走向数字、循环、气候中立和可持续的经济。Insight将帮助行业优化化学品/材料及其衍生产品的开发和生产，支持监管机构和政策制定者做出明智的决策，以实现更安全和更可持续的社会，并为全面解决SSBD铺平道路。

Safe and sustainable by design (SSbD) chemicals and materials are crucial to address the challenges of modern society. However, lack of stakeholders’ coordination, limited accessto relevant data, and absence ofstandardised methods have thusfar hampered the emergence of a comprehensive approach to SSbD. INSIGHT will overcome these challenges by developing an innovative framework for mechanistic impact assessment of chemicals/materials. The INSIGHT framework will consist of a multi-layered approach that integrates data, models, and impact outcome pathway (IOP) graphs. INSIGHT will also provide curated and user-friendly FAIR data and computational models/ workflows. INSIGHT aims to foster a paradigm shift in the assessment of sustainability and safety of chemicals and materials, from a fragmented situation to a holistic and integrated approach. INSIGHT will provide decision maps as a part of its integrated framework to guide users through the decision-making process, aiding them in evaluating the social, economic, health and environmental impacts of chemicals/materials in a more efficient and comprehensive manner. The INSIGHT project is fully aligned with the EU principles of safety and sustainability and the European Green Deal. INSIGHT will support the development of policies in the areas of neutrality, biodiversity protection, public health, and circular economy, thus aiding the development of a dynamic economy respecting planet Earth as a whole, avoiding harm to humans and the environment. By democratising the use of cutting-edge AI methods to SSbD, INSIGHT will drive innovation towards a digital, circular, climate-neutral and sustainable economy. INSIGHT will help the industry to optimise development and production of chemicals/materials and derived products, support regulators and policymakers in informed decision making towards safer and more sustainable society, and pave the way for a comprehensive approach to SSbD.