Personalised Adaptive Medicine

个体化药物配方是一个热门话题，但最先进的方法受到低可扩展性、成本和监管障碍的限制，而目前的丸剂配方工作受到液体形式或热熔添加方法的阻碍，带来了稳定性问题。这些瓶颈带来了巨大的社会代价，因为最近证明药物组合的协同促进可以显著改善治疗结果，同时已知将活性物质保持在理想的生理浓度窗口可以最大限度地提高效率并减少副作用。此外，多药是一个真正的问题，导致剂量错误和患者依从性的重大损失。最后，虽然大数据健康IT系统概念在遥远的未来具有收集大量可靠的基于证据的个性化医疗所需的剂量-患者数据的潜力，但提供此类数据的技术（通过双向数字信息流跟踪良好的患者/剂量程序）尚不具备。PERAMEDIC项目提出用一种突破性的解决方案来解决这些问题：一种用于个体化药物的独立药物配方系统，提供本地配制的、个性化定制的、分段释放的多药丸，具有固有的数字技术接口。该系统依赖于几种新技术的集成：个人释放轮廓，使用自适应工具路径的释放矩阵的原位3D打印，以及超精确的多通道粉末给药到密封的微室中。设想的设备将是一个桌面大小的药丸/胶囊印刷机，使用粉状药物罐和生物可吸收的聚合物基质材料。应用场景将首先是临床设置，然后是后期的药房位置和医疗实践，如全科医生办公室。PERAMEDIC将提供一个功能组合新技术的实验室规模概念验证原型系统，并提供未来技术的预览设计

Personalised drug formulation is a hot topic butstate of the art approaches are limited by low scalability, cost, and regulatory hurdles, while current polypill formulation efforts are hindered by liquid form or hot melt addition approaches, posing stability issues. These bottlenecks carry a great societal price, as the synergic boost of drug combinations was recently demonstrated to reach significant improvement in treatment outcomes, while keeping active substances in the ideal physiological concentration window is known to maximise efficiency and reduce side effects. Also, polypharmacy is a real problem leading to dosing errors and significant loss in patient adherence. Finally, while Big Data Health IT system concepts on the far horizon hold potential to gather the large amount of reliable dosage-patient data required for evidence-based personalised medicine, the technology to deliver such data – well-tracked patient/dosing procedures with bi-directional digital information flow – is missing. The PERAMEDIC project proposes to resolve these problems with a breakthrough solution: a stand-alone drug formulation system for personalised medicine, offering locally prepared, individually customised,segmented release polypills, with an inherently digital technology interface. The system relies on integrating several novel technologies: personal release profiles, in situ 3D printing of release matrix using adaptive toolpaths, and ultra-precise multichannel powder dosing of drugs into sealed microcompartments. The envisaged device would be a desktop-size pill/capsule printing machine, using canisters of powdered drugs and bioresorbable polymer matrix material. Application scenarios would be first clinical settings, then at later stage, pharmacy locations and medical practices such as GP’s office. PERAMEDIC will deliver a lab-scale proof-of-concept prototype system of the functionally combined novel technologies, with a preview design of the future technology