Core A - Administrative and Biostatistics Core

项目摘要-核心A行政与生物统计学核心（简称核心A）。核心A有两个相互关联的组成部分：行政统计和生物统计，它们有助于推进P01无法由其他实体完成的任务。在Anil Rustgi博士（也是核心A的总主任）的指导下，行政部门的首要目标或具体目标是协调项目之间的综合研究计划，并得到科学核心的大力支持。这一行政组成部分也促进了与宾夕法尼亚大学佩雷尔曼医学院、其NCI指定的艾布拉姆森癌症中心、外部机构、丰富项目、职业发展途径的互动，催化了我们P01的新方向，并确保P01得到明确和全心全意的机构支持。生物统计学部分由生物统计学教授Qi Long博士指导，位于宾夕法尼亚大学临床流行病学和生物统计学中心（CCEB）。其目标或具体目的是为项目在实验设计、统计建模/分析、数据解释和方法调查等方面提供全面支持。总的来说，这个核心使创新的基础科学研究能够将强大的临床前模型转化为食管癌治疗的新视角，这是该领域的一个主要空白。

PROJECT SUMMARY – CORE A The Administrative and Biostatistics Core (referred to as Core A). Core A has two interrelated components: Administrative and Biostatistics, which serve to advance the missions of the P01 that are not able to be served by other entities. The overriding objectives or Specific Aims of the Administrative component, under the direction of Dr. Anil Rustgi (also overall Director of Core A), is to coordinate an integrated research program between the Projects and with strong support from the scientific Cores. This Administrative component also facilitates interactions with Penn's Perelman's School of Medicine, its NCI designated Abramson Cancer Center, external institutions, enrichment programs, career development pathways, catalyzes new directions for our P01, and ensures that the P01 has the unequivocal and wholehearted institutional support. The Biostatistics component, under the direction of Dr. Qi Long, Professor of Biostatistics, is located in the Penn Center for Clinical Epidemiology and Biostatistics (CCEB). Its objectives or Specific Aims are to provide comprehensive support for the Projects in experimental design, statistical modeling/analysis, data interpretation and methodological investigations. In aggregate, this Core enables innovative basic science research with translation of robust preclinical models into new perspectives in therapeutics of esophageal cancer, which is a major gap in the field.