Core A: Administration

核心A将领导项目和核心的所有活动的科学、行政、财政和组织协调，以确保该计划项目赠款（PPG）满足所有拟议的科学目标。为了协调科学支持，核心A将促进互动和数据共享，提供监督、战略规划和对项目规划小组的评价。这将通过组织：1）由项目和核心领导人组成的执行委员会成员的双月会议，2）所有项目调查员和核心领导人的月度会议，3）与内部咨询委员会成员的半年会议，以及4）与外部咨询委员会成员的年度会议来实现，他们将审查整个项目规划小组的进展情况。为协调行政和财政支助，核心A将提供：1）授标前和授标后管理，包括每月财务余额和支出，编制年度预算和预测; 2）协助编写项目规划小组的年度进度报告，包括EAB的书面报告; 3）保证项目规划小组履行其报告和合规义务。这些面对面的会议将确保进展和数据共享，以及实验方案的统一性。

ABSTRACT Core A will provide the leadership for scientific, administrative, fiscal, and organizational coordination of all the activities of the Projects and Cores to ensure this Program Project Grant (PPG) meets all of the proposed scientific goals. To coordinate scientific support, Core A will facilitate interactions and data sharing, provide oversight, strategic planning and evaluation of the PPG. This will be accomplished through organizing: 1) bimonthly meetings of the Executive Committee members consisting of the Project and Core leaders, 2) monthly meetings of all Project investigators and Core leaders, 3) biannual meetings with the Internal Advisory Board members, and 4) annual meetings with the External Advisory Board members, who will review progress of the PPG as a whole. To coordinate administrative and fiscal support, Core A will provide 1) pre- and post-award management, including monthly financial balances and expenditures, preparation of annual budgets and projections, 2) assistance in annual progress reports on the PPG, including the written report of the EAB, and 3) assurance that the PPG meets its reporting and compliance obligations. These face-to-face meetings will ensure progress and data sharing, as well as uniformity in experimental protocols.