CHEMICAL SCREENING AND OPTIMIZATION FACILITY - MANAGEMENT, ADMINISTRATION AND DATABASE CORE FUNCTION ACTIVITIES

化学筛选和优化设施 - 管理、行政和数据库核心功能活动

• 批准号: 10942871
• 负责人: LEYI GONG
• 金额: $ 32.67万
• 依托单位: SRI INTERNATIONAL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-27 至 2024-09-26
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10942871
• 关键词: Adenomyosis; Archives; Bacterial Infections; Biological; Chemicals; Contraceptive Agents; Contraceptive methods; Data; Databases; Down Syndrome; Dysmenorrhea; Equipment; Equipment and supply inventories; Fetal Growth Retardation; Fibroid Tumor; Gestational Diabetes; Gynecologic; Health; Infertility; Inflammation; Lactation; Maintenance; Mission; Muscular Dystrophies; National Institute of Child Health and Human Development; Natural Products; Necrotizing Enterocolitis; Pelvic Pain; Perinatal; Pituitary-dependent Cushing' s disease; Placenta; Polycystic Ovary Syndrome; Polymers; Pre-Eclampsia; Premature Birth; Production; Reproductive Health; Research; Rett Syndrome; Role; Sepsis; United States National Institutes of Health; Virus Diseases; Vulvodynia; autism spectrum disorder; drug development; endometriosis; improved; in vivo evaluation; mastitis; microbiome; novel; screening; small molecule

This task is to conduct the core administrative activities, including project management, as well as storage of chemical and biological inventory, archived documents and data, maintenance of equipment, and continued database maintenance activities in the Chemical Screening and Optimization Facility (CSOF) to support the mission of contraceptive drug development in the Contraception Research Branch (CRB), NICHD, NIH. The Chemical Screening and Optimization Facility (CSOF) fulfills a unique role by identifying, optimizing and conducting production identified small molecules for contraceptive and reproductive health related (e.g., infertility, polycystic ovarian syndrome, fibroids, endometriosis, dysmenorrhea, adenomyosis, gynecologic and/or pelvic pain, and vulvodynia, premature birth, placenta health, improving lactation quality and quantity, preeclampsia, perinatal microbiome, gestational diabetes, inflammation, bacterial infections, viral infections, necrotizing enterocolitis, bronchopulmonary dyplasia, pre-term birth, fetal growth restriction, mastitis, Cushing's disease, Down Syndrome, Ricketts, Muscular Dystrophy, Rett syndrome, sepsis, or Autism) research. One approach is to conduct scalable quantity projects of identified small molecule(s) (e.g., natural product) and/or large molecule (e.g., polymer) that afford a contraceptive effect against a validated target or as a treatment for an identified reproductive health related indication. This facility will also be responsible for the production of chemical material for preliminary in vivo testing. It is expected that multiple independent projects will be performed simultaneously by the CSOF. Appropriate oversight of these projects will be essential for their successful execution.

这项任务是在化学品筛选和优化设施(CSOF)开展核心行政活动，包括项目管理以及储存化学和生物库存、存档文件和数据、设备维护和持续的数据库维护活动，以支持NIH NICHD避孕研究处(CRB)的避孕药物开发任务。 化学筛选和优化设施(CSOF)通过识别、优化和进行与避孕和生殖健康相关的小分子研究(例如：不孕症、多囊卵巢综合征、子宫肌瘤、子宫内膜异位症、痛经、子宫腺肌症、妇科和/或盆腔疼痛、外阴疼痛、早产、胎盘健康、提高哺乳质量和数量、先兆子痫、围产期微生物群、妊娠期糖尿病、炎症、细菌感染、病毒感染、坏死性小肠结肠炎、支气管肺发育不良、早产、胎儿生长受限、乳腺炎、库兴氏病、唐氏综合症、立克病、肌肉萎缩、Rett综合征、败血症或自闭症)来发挥独特的作用。一种办法是对已确定的小分子(如天然产物S)和/或大分子(如聚合物)进行可扩展的数量项目，以针对已确认的目标提供避孕效果，或作为已确定的生殖健康相关适应症的治疗。该设施还将负责生产用于体内初步试验的化学材料。预计民间社会保障基金将同时执行多个独立项目。对这些项目的适当监督对于它们的成功执行至关重要。