CHEMICAL SCREENING AND OPTIMIZATION FACILITY - MANAGEMENT, ADMINISTRATION AND DATABASE CORE FUNCTION ACTIVITIES

化学筛选和优化设施 - 管理、行政和数据库核心功能活动

• 批准号: 10942871
• 负责人: LEYI GONG
• 金额: $ 32.67万
• 依托单位: SRI INTERNATIONAL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-27 至 2024-09-26
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10942871
• 关键词: Adenomyosis; Archives; Bacterial Infections; Biological; Chemicals; Contraceptive Agents; Contraceptive methods; Data; Databases; Down Syndrome; Dysmenorrhea; Equipment; Equipment and supply inventories; Fetal Growth Retardation; Fibroid Tumor; Gestational Diabetes; Gynecologic; Health; Infertility; Inflammation; Lactation; Maintenance; Mission; Muscular Dystrophies; National Institute of Child Health and Human Development; Natural Products; Necrotizing Enterocolitis; Pelvic Pain; Perinatal; Pituitary-dependent Cushing' s disease; Placenta; Polycystic Ovary Syndrome; Polymers; Pre-Eclampsia; Premature Birth; Production; Reproductive Health; Research; Rett Syndrome; Role; Sepsis; United States National Institutes of Health; Virus Diseases; Vulvodynia; autism spectrum disorder; drug development; endometriosis; improved; in vivo evaluation; mastitis; microbiome; novel; screening; small molecule

This task is to conduct the core administrative activities, including project management, as well as storage of chemical and biological inventory, archived documents and data, maintenance of equipment, and continued database maintenance activities in the Chemical Screening and Optimization Facility (CSOF) to support the mission of contraceptive drug development in the Contraception Research Branch (CRB), NICHD, NIH. The Chemical Screening and Optimization Facility (CSOF) fulfills a unique role by identifying, optimizing and conducting production identified small molecules for contraceptive and reproductive health related (e.g., infertility, polycystic ovarian syndrome, fibroids, endometriosis, dysmenorrhea, adenomyosis, gynecologic and/or pelvic pain, and vulvodynia, premature birth, placenta health, improving lactation quality and quantity, preeclampsia, perinatal microbiome, gestational diabetes, inflammation, bacterial infections, viral infections, necrotizing enterocolitis, bronchopulmonary dyplasia, pre-term birth, fetal growth restriction, mastitis, Cushing's disease, Down Syndrome, Ricketts, Muscular Dystrophy, Rett syndrome, sepsis, or Autism) research. One approach is to conduct scalable quantity projects of identified small molecule(s) (e.g., natural product) and/or large molecule (e.g., polymer) that afford a contraceptive effect against a validated target or as a treatment for an identified reproductive health related indication. This facility will also be responsible for the production of chemical material for preliminary in vivo testing. It is expected that multiple independent projects will be performed simultaneously by the CSOF. Appropriate oversight of these projects will be essential for their successful execution.

本任务是在美国国立卫生研究院NICHD避孕研究处（CRB）进行核心行政活动，包括项目管理，以及化学和生物清单的存储，存档文件和数据，设备的维护和持续的数据库维护活动，以支持避孕药物开发的使命。