CHEMICAL SCREENING AND OPTIMIZATION FACILITY - MANAGEMENT, ADMINISTRATION AND DATABASE CORE FUNCTION ACTIVITIES

化学筛选和优化设施 - 管理、行政和数据库核心功能活动

• 批准号: 10942871
• 负责人: LEYI GONG
• 金额: $ 32.67万
• 依托单位: SRI INTERNATIONAL
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-27 至 2024-09-26
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10942871
• 关键词: Adenomyosis; Archives; Bacterial Infections; Biological; Chemicals; Contraceptive Agents; Contraceptive methods; Data; Databases; Down Syndrome; Dysmenorrhea; Equipment; Equipment and supply inventories; Fetal Growth Retardation; Fibroid Tumor; Gestational Diabetes; Gynecologic; Health; Infertility; Inflammation; Lactation; Maintenance; Mission; Muscular Dystrophies; National Institute of Child Health and Human Development; Natural Products; Necrotizing Enterocolitis; Pelvic Pain; Perinatal; Pituitary-dependent Cushing' s disease; Placenta; Polycystic Ovary Syndrome; Polymers; Pre-Eclampsia; Premature Birth; Production; Reproductive Health; Research; Rett Syndrome; Role; Sepsis; United States National Institutes of Health; Virus Diseases; Vulvodynia; autism spectrum disorder; drug development; endometriosis; improved; in vivo evaluation; mastitis; microbiome; novel; screening; small molecule

This task is to conduct the core administrative activities, including project management, as well as storage of chemical and biological inventory, archived documents and data, maintenance of equipment, and continued database maintenance activities in the Chemical Screening and Optimization Facility (CSOF) to support the mission of contraceptive drug development in the Contraception Research Branch (CRB), NICHD, NIH. The Chemical Screening and Optimization Facility (CSOF) fulfills a unique role by identifying, optimizing and conducting production identified small molecules for contraceptive and reproductive health related (e.g., infertility, polycystic ovarian syndrome, fibroids, endometriosis, dysmenorrhea, adenomyosis, gynecologic and/or pelvic pain, and vulvodynia, premature birth, placenta health, improving lactation quality and quantity, preeclampsia, perinatal microbiome, gestational diabetes, inflammation, bacterial infections, viral infections, necrotizing enterocolitis, bronchopulmonary dyplasia, pre-term birth, fetal growth restriction, mastitis, Cushing's disease, Down Syndrome, Ricketts, Muscular Dystrophy, Rett syndrome, sepsis, or Autism) research. One approach is to conduct scalable quantity projects of identified small molecule(s) (e.g., natural product) and/or large molecule (e.g., polymer) that afford a contraceptive effect against a validated target or as a treatment for an identified reproductive health related indication. This facility will also be responsible for the production of chemical material for preliminary in vivo testing. It is expected that multiple independent projects will be performed simultaneously by the CSOF. Appropriate oversight of these projects will be essential for their successful execution.

这项任务是开展核心行政活动，包括项目管理，以及化学品和生物库存的储存、存档文件和数据、设备维护，以及化学品筛选和优化设施（CSOF）的持续数据库维护活动，以支持NICHD、NIH避孕研究分支（CRB）的避孕药物开发使命。 化学筛选和优化设施（CSOF）通过鉴定、优化和进行生产鉴定的用于避孕和生殖健康相关的小分子（例如，不孕症、多囊卵巢综合征、纤维瘤、子宫内膜异位症、痛经、子宫腺肌病、妇科和/或盆腔疼痛和外阴痛、早产、胎盘健康、改善泌乳质量和数量、先兆子痫、围产期微生物组、妊娠糖尿病、炎症、细菌感染、病毒感染、坏死性小肠结肠炎、支气管肺发育不良、早产、胎儿生长受限、乳腺炎、库欣病，唐氏综合征、里基茨综合征、肌营养不良、雷特综合征、败血症或自闭症）研究。一种方法是进行鉴定的小分子（例如，天然产物）和/或大分子（例如，聚合物），其提供针对经验证的目标的避孕效果或作为针对经鉴定的生殖健康相关适应症的治疗。 该机构还将负责生产用于初步体内试验的化学材料。预计CSOF将同时执行多个独立项目。对这些项目的适当监督对于项目的成功执行至关重要。