BERTI; Biomedical implant with Exceptional Resistance to Tribo-bio-corrosion and with Inherent antimicrobial properties

BERTI项目（具有优异的摩擦生物腐蚀抗性和固有抗菌性能的生物医学植入物）的目标是开发一种创新的关节置换物，其涂层可最大限度地减少聚乙烯和金属磨损碎屑，防止金属离子释放并促进抗菌剂的释放。该项目将确定一种方法，确定对患者中观察到的磨损碎屑的有害反应的驱动因素。这些信息将用于优化最近开发的物理气相沉积涂层，该涂层在提供抗菌剂的同时最大限度地减少磨损和摩擦生物腐蚀。此外，该项目还将建立一项患者对植入物离子释放敏感性的试验。这将有助于确定从新型涂层植入物中受益最多的患者群体，并将为他们和更广泛的人群提供具有卓越生物相容性、寿命和抗菌性能的世界领先的关节置换术。BERTI项目将最终延长骨科植入物的寿命，减少翻修手术的数量，使英国和更广泛的经济以及患者受益。

The objective of project BERTI (Biomedical implant with Exceptional Resistance to Tribo-bio-corrosion and with Inherent antimicrobial properties) is to develop an innovative joint replacement with a coating that minimises polyethylene and metal wear debris, prevents metal ion release and promotes the release of antimicrobial agents. The project will determine a method that establishes drivers for the detrimental responses to wear debris observed in patients. This information will be used to optimise a recently develop physical-vapour deposition coating that minimises wear and tribo-bio-corrosion while delivering an antimicrobial agent. In addition, the project will establish a test for patient susceptibility to ions release from implants. This will help identify patient cohorts who would benefit most from the novel coated implants, and will deliver to them, and to the wider population, a world-leading joint replacement with exceptional biocompatibility, longevity and antimicrobial properties. Project BERTI will ultimately increase the longevity of orthopaedic implants, reducing the number of revision surgeries, benefiting the UK and wider economy, and the patient.