TRD2: Circular Ranging OCT

项目摘要 TRD-2 TRD项目2将开发基于新型光学圆形测距(CR)架构的成像平台 相干层析成像。具体目标1解决在开放手术中使用OCT的长期挑战。 传统的方法使外科医生背上笨重的设备，并需要中断手术。 工作流程。我们将利用CR的深度独立性来实现头戴式OCT显微镜，该显微镜 可连续测量手术野。此OCT放大镜平台将专门开发以提供 改善了神经的可视化，以防止意外伤害这些脆弱和关键的组织，从而 避免了一些最可怕的外科疾病。具体目标#2整合了 利用极快的视网膜CR-OCT技术进行定量血流成像，为宽视场提供平台 人类视网膜的血管造影术和定量血流图。定量血流成像将使 全面、脉搏分辨的非毛细血管视网膜血管网络图，将研究人员定位到 破译视网膜血流和疾病之间的相互作用。广域血管造影术将减少 限制临床医生和科学家通过这些目标对外围视网膜进行可靠和常规的成像， TRD-2将开发、验证创新技术，并向我们合作的调查人员和 更广泛的生物医学界。

Project Summary TRD-2 TRD project 2 will develop imaging platforms based on novel circular ranging (CR) architectures of optical coherence tomography. Specific Aim #1 addresses long-standing challenges to using OCT in open surgery. Conventional approaches burdened the surgeon with cumbersome equipment and required disruptions in workflow. We will leverage the depth-independence of CR to enable a head-mounted OCT microscope that can continuously survey the surgical field. This OCT loupe platform will be specifically developed to provide improved visualization of nerves to prevent accidental injury to these delicate and critical tissues, and thereby avoiding some of the most feared surgical morbidities. Specific Aim #2 integrates recent advancements in quantitative flow imaging with extremely rapid retinal CR-OCT technology to enable a platform for wide-field angiography and quantitative flow mapping in the human retina. Quantitative flow imaging will enable comprehensive, pulse resolved maps of the non-capillary retinal vascular networks, positioning investigators to decipher the interaction of retinal perfusion and disease. Wide-field angiography will reduce barriers that have limited clinicians and scientists from reliably and routinely imaging the peripheral retina Through these aims, TRD-2 will develop, validate, and deliver innovative technologies to our collaborating investigators and to the broader biomedical community.