EBRAINS 2.0: A Research Infrastructure to Advance Neuroscience and Brain Health

EBRAINS是一个协作性的欧洲研究基础设施，旨在促进和加速神经科学和大脑健康方面的进展。这个创新的基础设施是人脑项目(HBP)的遗产，是一个生态系统，来自不同学科的研究人员、临床医生和专家聚集在一起，探索和分析大脑的复杂性-从分子和细胞水平到整个器官的功能。因此，该项目旨在创建从微观到宏观的脑图谱新标准，将健康和病理大脑中的基础多层次数据和连接与图谱和模型联系起来，通过建模和模拟创建数字双胞胎，以及为公平的神经科学数据提供独特、优秀和首选的服务。EBRAINS 2.0的总体目标是通过专门和成熟的软件工具加深对大脑结构和功能的了解，促进神经精神疾病更有效的治疗、新药、诊断和预防措施的开发。我们预计，EBRAINS 2.0将催化在HPC上运行的大规模模型领域的进展，走向Exascale，并导致神经启发计算的创新解决方案，以及神经机器人和人工智能等认知技术。先进的数字建模和数据分析能力将使神经科学以外的社区受益，如生物医学。我们将推进EBRAINS技术、平台服务和基础设施路线图，教育和培训来自学术界、产业界和中小企业的新用户和开发人员，确保知识转移。通过与欧洲数据空间、EOSC和EuroHPC Ju、卓越中心和其他倡议建立牢固的联系，EBRAINS 2.0将成为欧洲基础设施领域的神经科学中心。在全球范围内，EBRAINS 2.0将为数字神经科学的新时代做出强有力的贡献，并培育欧洲在该领域的领导地位。

EBRAINS is a collaborative European Research Infrastructure designed to advance and accelerate progress in neuroscience and brain health. This innovative infrastructure, a legacy of the Human Brain Project (HBP), is an ecosystem where researchers, clinicians and experts from various disciplines converge to explore and analyze brain complexity – from molecular and cellular levels to the functioning of the entire organ. Therefore, the project aims to create a new standard for brain atlases from the micro- to the macro-scale, link foundational multi-level data and connectomes in the healthy and pathological brain with atlases and models, create digital twins through modelling and simulation as well as unique, excellent, and preferred services for FAIR neuroscience data. The overarching goal of EBRAINS 2.0 is to foster a deeper understanding of brain structure and function with dedicated and mature software tools, to facilitate the development of more effective treatments, new drugs, diagnostics and preventive measures for neuro-psychiatric disorders. We expect that EBRAINS 2.0 catalyzes progress in the field of large-scale models running on HPC towards Exascale and leads to innovative solutions for neuro-inspired computing, and cognitive technologies such as neurorobotics and AI. Sophisticated digital modeling and data analytics capabilities will benefit communities beyond neuroscience, such as biomedicine. We will advance EBRAINS technology, platform services and the base infrastructure roadmap, educate and train a new community of users and developers from academia, industry and SMEs, and ensure knowledge transfer. EBRAINS 2.0 will become the neuroscience hub in the European infrastructure landscape, through building strong links with the European data spaces, EOSC and EuroHPC JU, centers of excellences and other initiatives. Globally, EBRAINS 2.0 will make a strong contribution to the new era of digital neuroscience and foster European leadership in this field.